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Volume 47, Issue 8
Displaying 1-11 of 11 articles from this issue
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[in Japanese]2004 Volume 47 Issue 8 Pages 617
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 8 Pages 619-621
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]2004 Volume 47 Issue 8 Pages 622-625
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 8 Pages 626-628
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 8 Pages 629-631
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]2004 Volume 47 Issue 8 Pages 632-634
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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Naoko Enosawa, Minoru Inoue, Tsutomu Sato, Fumiko Otsuka, Kanemi Aoki, ...2004 Volume 47 Issue 8 Pages 635-641
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSIn diet therapy for weight reduction in obesity, an issue is adaptive phenomenon (AP) in which weight loss stops. We evaluated avoiding such AP in obese type 2 diabetic patients. Patients who could be admitted for 8 weeks were put on low calorie diets (LCDs) of 1, 000 kcal/day for men and 800kcal/day for women. To avoid AP, LCDs were switched to standard diets (35kcal/kg standard body weight) for 1 week, then LCDs were started again (Group A, n=15). As a control for the age-matched group, LCDs were continued for 8 weeks despite AP (Group B, n=14). In Group A, all patients avoid AP and continued to lose weight. At 8 weeks after the start of treatment, 12.3±2.5% weight loss was noted. In Group B, the rate of decrease in body weight was 8.8±2.7%. Our method in which energy intake was increased for a short period followed by a return to LCDs was useful for avoiding AP and enhancing weight loss during the same period.View full abstractDownload PDF (1347K) -
Shigeki Yamamoto, Hiroshi Fujimoto, Hiroyuki Nakao, Takahiko Katoh, Is ...2004 Volume 47 Issue 8 Pages 643-648
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSSteroid-induced diabetes mellitus is one of the highly frequent side effect of glucocorticoid agents, and is suggested to be due to insulin resistance. The new oral hypoglycemic agent pioglitazone, which improves insulin resistance, is being used clinically to treat diabetes mellitus.
We randomly classified 40 cases into two groups of 20 subjects each. Pioglitazone was administered to one group and not to the other. We conducted an oral glucose tolerance test (OGTT) on the two groups before and six months after the administration of pioglitazone, then examined changes in both plasma glucose and plasma immunoreactive insulin.
As a result, hemoglobin Aic (HbA1c) decreased from 7.88±0.28% to 6.64±0.10%(mean±SE) six months after the administration of pioglitazone. Pioglitazone significantly decreased two-hour plasma glucose (291.7±13.36 mg/dl to 203.0±8.93 mg/dl, mean±SE), which revealed insulin resistance in skeletal muscle, and decreased HOMA-R (3.36±0.28% to 1.98±0.27, mean±SE), which revealed hepatic glucose production.
In conclusion, we showed that both control of plasma glucose and of insulin resistance were improved by administration of pioglitazone, which potentiates insulin action and reduces insulin resistance. Our results suggest that the administration of pioglitazone has positive clinical effects on steroid-induced diabetes mellitus.View full abstractDownload PDF (1060K) -
Mizuho Tanaka, Masanobu Takeda, Ryou Teruya, Makiko Ogata, Ayako Nakaj ...2004 Volume 47 Issue 8 Pages 649-654
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 35-year-old man with type 1 diabetes mellitus and chronic renal failure requiring hemodialysis was diagnosed with diabetes mellitus at age 14 and began dialysis therapy when 34 years old. HbA1c was 8.5%, and he was hospitalized to control plasma glucose. On admission, he reported pain and swelling of the hand, shoulder, and knee joints. Serum C-reactive protein was 15.7mg/dl and erythrocyte sedimentation 86mm/h, suggesting severe inflammation. He was diagnosed with rheumatoid arthritis. Symptoms resolved immediately after steroid therapy was started.
Several cases of type 1 diabetes with other autoimmune diseases have been reported. Chronic renal failure is known to be associated with severe immune suppression. So it is considered that chronic renal failure and collagen diseases are hard to complicate with. Membrane use during hemodialysis reportedly activates leukocytes and uremia stimulates the production of circulating inflammatory cytokines. Further studies are therefore required to clarify the mechanism of rheumatoid arthritis occurring with type 1 diabetes mellitus and end-stage renal disease.View full abstractDownload PDF (1643K) -
Hiroshi Onuma, Haruhiko Osawa, Akiko Murakami, Namiko Takeda, Masaaki ...2004 Volume 47 Issue 8 Pages 655-659
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe report two cases of obese young men with high serum insulin and acanthosis nigricans. Case 1 was a 16-year-old man (173 cm tall, 113 kg weight, BMI 37.7 kg/m2). A 75 g oral glucose tolerance test (75 g OGTT) showed impaired glucose tolerance and hyperinsulinemia (fasting IRI; 40μU/ml, highest IRI; 490μU/ml). Case 2 was a 21-year-old man (160.3cm tall, 91 kg weight, BMI 34.5kg/m2). A 75 9 OGTT showed normal glucose tolerance and hyperinsulinemia (fasting IRI; 81μU/ml, highest IRI; 250mU/ml). In both cases, hyperinsulinemia was improved after weight loss. Although missence mutations in the insulin receptor gene were not identified in eithercase, Trp64Arg heterozygous polymorphism in the β3 adrenergic receptor gene and Pro12 homozygous polymorphism in the PPARγ gene were both identified in these two cases.View full abstractDownload PDF (941K) -
2004 Volume 47 Issue 8 Pages 661-704
Published: August 30, 2004
Released on J-STAGE: March 02, 2011
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