Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 59, Issue 8
Displaying 1-9 of 9 articles from this issue
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Feature
Diabetes and Heart Failure
Original Article
Pathophysiology, Metabolic Abnormalities, Complications
  • The Usefulness of Evaluating the Urinary Liver-Type Fatty Acid-Binding Protein (Urinary L-FABP) Levels in Diabetic Nephropathy in Patients With Type 2 Diabetes
    Tetsuo Hayakawa, Akiko Takazakura, Akiko Shimizu
    2016 Volume 59 Issue 8 Pages 569-575
    Published: August 20, 2016
    Released on J-STAGE: August 30, 2016
    DOIhttps://doi.org/10.11213/tonyobyo.59.569
    JOURNAL FREE ACCESS
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    This study investigated the urinary liver-type fatty acid-binding protein (urinary L-FABP) levels and nephropathy in 695 patients with type 2 diabetes. Abnormal urinary L-FABP levels were detected in 9.9 % of the patients, which was lower than the percentage of patients with abnormal albuminuria levels (24.6 %). We found that the patients in the abnormal urinary L-FABP group showed a low eGFR and a high level of albuminuria. The eGFR decreased and urinary L-FABP increased with an increase in the albuminuria level. We compared the patients with normal and abnormal levels of urinary L-FABP in combination with normoalbuminuria, microalbuminuria, and macroalbuminuria. The group of patients with abnormal urinary L-FABP and microalbuminuria group showed a lower eGFR than the normal urinary L-FABP and microalbuminuria group. Among the patients with microalbuminuria, those with an abnormal level of urinary L-FABP showed a lower eGFR. We suspect that the renal function was decreased by the increased number of complicated kidney lesions in the group of patients with abnormal levels of urinary L-FABP and microalbuminuria.

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Case Report
  • A Case of Diabetic Lipemia at the Onset of Type 1 Diabetes Mellitus in 4-Year-Old Girl
    Atsushi Hattori, Junya Eto, Kenichi Miyako
    2016 Volume 59 Issue 8 Pages 576-581
    Published: August 20, 2016
    Released on J-STAGE: August 30, 2016
    DOIhttps://doi.org/10.11213/tonyobyo.59.576
    JOURNAL FREE ACCESS
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    A four-year-old girl was referred to our department for hyperglycemia and ketosis after six months of fatigue, polydipsia, and polyuria. She had ketosis and mild metabolic acidosis; laboratory tests demonstrated that her serum glucose was 530 mg/dL, HbA1c was 16.9 %, and serum triglyceride was as high as 6,915 mg/dL. We performed an analysis of her lipoprotein cholesterol levels, which revealed a high level of very-low-density lipoprotein cholesterol, leading to the diagnosis of diabetic lipemia. The hypertriglyceridemia was improved shortly after the initiation of insulin therapy without a complication of acute pancreatitis. Predisposing factors of diabetic lipemia may include a long duration of insulin insufficiency and decreased activity of lipoprotein lipase. We should therefore be alert for the possibility of patients presenting with diabetic lipemia, even in pediatric practice, as it may cause severe complications, such as acute pancreatitis.

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Proceeding of the Local Societies
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