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Volume 42, Issue 6
Displaying 1-16 of 16 articles from this issue
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[in Japanese]1999 Volume 42 Issue 6 Pages 407
Published: June 30, 1999
Released on J-STAGE: March 02, 2011
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[in Japanese]1999 Volume 42 Issue 6 Pages 409-410
Published: June 30, 1999
Released on J-STAGE: March 02, 2011
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[in Japanese]1999 Volume 42 Issue 6 Pages 411-413
Published: June 30, 1999
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[in Japanese], [in Japanese]1999 Volume 42 Issue 6 Pages 415-417
Published: June 30, 1999
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[in Japanese], [in Japanese]1999 Volume 42 Issue 6 Pages 419-422
Published: June 30, 1999
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[in Japanese]1999 Volume 42 Issue 6 Pages 423-425
Published: June 30, 1999
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[in Japanese], [in Japanese]1999 Volume 42 Issue 6 Pages 427-429
Published: June 30, 1999
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Tadayoshi Takegoshi, Chikashi Kitoh, Takanobu Wakasugi, Toshimi Shimad ...1999 Volume 42 Issue 6 Pages 431-438
Published: June 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSHyper-homocysteinemia has been recognized as one of the risk factors for atherosclerosis and premature vascular disease. Since hyper-homocysteinemia is directly related to the incidence of cardiovascular disease, we have investigated the possibility that its concentrations can modulate the development of atherosclerosis in patients with diabetes mellitus (DM). Seventy diabetic patients (36 males, 34 females, 61±9 years) without apparent renal insufficiency or hepatic involvement were studied. The control group was composed of 176 healthy normal subjects (95 males, 81 females, 51±9 years). Homocysteine levels were determined in plasma by the fluorometric highperformance liquid chromatography. The presence of aortic plaques was assessed by echocardiography by using a high resolution B-mode echo apparatus (HITACHI EUB-045, 10 Mhz linear array probe). Mean (±SD) levels of plasma homocysteine were no higher in DM group than in the control group. In diabetic patients, plasma homocysteine levels were positively correlated with serum creatinine and severity of diabetic retinopathy by multiple logistic regression analysis. Carotid intima-media thickness and plaque prevalent rate were significantly increased in diabetics than in normal subjects. Plasma homocysteine levels were significantly increased in plaque prevalent subjects.These results suggest that hyperhomocysteinemia may be induced in relation to aging and the degree of renal insufficiency, and may partially explain the observed accelaration of atherosclerosis in diabetic patients.View full abstractDownload PDF (1404K) -
Taro Sakaue, Tsutomu Hirano, Gen Yoshino, Keiko Sakai, Sigenobu Saito, ...1999 Volume 42 Issue 6 Pages 439-446
Published: June 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo explore how plasma levels of remnant lipoproteins are influenced by diabetic nephropathy, we measured intermediate-density lipoprotein (IDL, d=1.006-1.019) and remnant-like particle (RLP) cholesterol in type 2 diabetic patients with various degrees of kidney damage and 17 nondiabetic control subjects. Plasma triglyceride (TG) levels in diabetic patients without nephropathy were identical to those in nondiabetic controls, whereas these levels were significantly increased in diabetic patients with microalbuminuria, and were further increased in those with overt proteinuria and chronic renal failure. Plasma apoprotein (apo) B and total-cholesterol levels were increased in diabetic patients with microalbuminuria and overt proteinuria, but levels were decreased when accompanied with chronic renal failure. Similarly, concentrations of TG and cholesterol in IDL were substantially increased in diabetic patients with diabetic nephropathy including microalbuminuria. IDL-apo B levels were not increased in normoalbuminuric and microalbuminuric diabetic patients, but substantially increased in patients with overt proteinuria and with renal failure. RLP-cholesterol was significantly increased in patients with overt diabetic nephropathy.
There was no correlation between glycemic control and concentrations of remnant lipoproteins. These results suggest that diabetic nephropathy including microalbuminuria plays an important role in the accumulation of atherogenic remnant lipoproteins in diabetic patients, and that nephropathy is associtated with a high prevalence of atherosclerotic disease in these populations.View full abstractDownload PDF (1521K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 6 Pages 447-450
Published: June 30, 1999
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[in Japanese]1999 Volume 42 Issue 6 Pages 451-456
Published: June 30, 1999
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 6 Pages 457-460
Published: June 30, 1999
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Yasushi Azami1999 Volume 42 Issue 6 Pages 461-465
Published: June 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA-69-year-old demented woman who had appetite loss was referred to this hospital in June 17, 1997. She was diagnosed as having diabetes mellitus (DM) and Alzheimer's disease. Conventional insulin therapy was started. Her basal cortisol level and cortisol circadian rhythm were elevated (29.8 μg/dl at 07: 00) and the postdexamethasone (1 mg) cortisol level was not completely suppressed (4.7μg/dl). She was discharged on August 30, 1997. However, she was readmitted because of loss of consciousness on September 6, 1997. Her blood glucose level was 969 mg/dl, serum CK level was 1, 137 IU/l, and serum myoglobin level was 1, 784 mg/dl. Her CRP was within normal limits and urinary ketone body was negative. She was diagnosed as having hyperosmolar nonketotic coma (HNKC) with rhabdomyolysis. Transfusion of half saline and continuous administration of insulin were started, and on the fifth hospital day, her consciousness and electrolytes substantially returned to normal. CK and myoglobin levels gradually decreased. In this case, the development of HNKC was assumed to be precipitated by an acute viral infection because there were no findings of bacterial infection by diagnostic imaging techniques. The above described clinical data of this patient is suggestive of the close association between the onset of HNKC and the prolonged glucocorticoid hypersecretion under stress conditions that exists in DM when accompanied by Alzheimer's disease.View full abstractDownload PDF (1692K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1999 Volume 42 Issue 6 Pages 467-470
Published: June 30, 1999
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 6 Pages 471-476
Published: June 30, 1999
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1999 Volume 42 Issue 6 Pages 477-493
Published: June 30, 1999
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