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Volume 40, Issue 1
Displaying 1-6 of 6 articles from this issue
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Keiko Nomoto1997 Volume 40 Issue 1 Pages 1-8
Published: January 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo determine the acute effects of ethanol administration on the development of nephropathy in Wistar rats with streptozotocin (STZ)-induced diabetes, changes in plasma glucose, creatinine clearance (Ccr) and urinary albumin excretion (UAE) rate were observed for 5 consecutive days. Moreover, at the end of the experiment the number of anionic sites (AS) on the lamina rara externa of the glomerular basement membrane (GBM) were evaluated in the following four groups:(1) control rats, (2) ethanol-administered control rats (EtOH rats), (3) STZ-induced diabetic rats (STZ rats), (4) ethanol-administered STZrats (STZ+EtOHrats).
Plasma glucose concentrations were increased after one dose of ethanol on Day 5. Elevation of Ccr was found in STZ rats and STZ+EtOH rats, and levels were significantly (p<0.01) higher in the latter than in the former. The increases in UAE were consistent with the Ccr results. The number of AS was decreased in the two STZ groups, being significantly (p<0.001) greater in the STZ+EtOH rats than in the STZ rats.
From these results, ethanol loading increased in UAE possibly via induction of plasma glucose elevation and enhanced permeability of the GBM for albumin.View full abstractDownload PDF (3392K) -
Prevalence, Clinical Features, Risk Factors, and PrognosisYasuo Kida, Atsunori Kashiwagi, Rie Ide, Tohru Kawabata, Katsuhiko Sak ...1997 Volume 40 Issue 1 Pages 9-15
Published: January 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSBaroreflex dysfunction is thought to be a result of both parasympathetic and sympathetic neuropathy in non-insulin dependent diabetes mellitus (NIDDM). Herein, the prevalence, clinical features, risk factors, and prognosis of orthostatic hypotension (OH) were assessed in 385 NIDDM patients.(1) The prevalence of OH was 15%(n=57).(2) The subjects with OH more frequently had hypertension, and both micro-and macrovascular complications when compared with those of subjects without OH.(3) There was a significant positive correlation between the magnitude of orthostatic decrease in systolic blood pressure and both supine systolic and diastolic blood pres sures.(4) Multivariate analysis established hypertension, aging, duration of diabetes, the coefficient of R-R interval variation and nephropathy as independent risk factors for OH.(5) During the brief observation period, 10 OH subjects, including 3 sudden death cases, died (mortality=65/1000 person-year) indicating a poor prognosis for those with OH.View full abstractDownload PDF (1121K) -
Yukihiro Banda, Yoshikane Tachibana, Ken-ichi Fukuoka, Taisyu Toya, No ...1997 Volume 40 Issue 1 Pages 17-24
Published: January 30, 1997
Released on J-STAGE: August 04, 2011
JOURNAL FREE ACCESSTo clarify the most useful long-term glycemic control marker in chronic liver disease, we simultaneously evaluated daily profiles of blood glucose (BG), various liver function tests and four long-term glycemic control markers {hemoglobin Aic (HbA1c), fructosamine (FRA), glycated albumin (GA) and 1, 5-anhydroglucitol (1, 5-AG)} in 85 inpatients with chronic liver diseases who had been maintained in stable condition for at least two weeks. There were strong significant correlations between average BG calculated from daily BG profiles and all four markers (r=0.60-0.83). Evaluation in normal BG (both 110 mg/dlfor preprandial levels and 160 mg/dlfor postprandial levels) and high BG (200 mg/dlfor postprandial levels) groups revealed that HbAic and 1, 5-AG were shifted toward lower levels while FRA and GA were shifted toward higher levels, with these deviations accounting for 21-24% of the abnormal values observed. In examination of the normal BG group alone, the hepaplastin test (HPT) revealed the most significant correlations with each of the glycemic control markers (HbA1c: r=0.49; GA:-0.68; FRA:-0.59; 1, 5-AG: 0.42.) From these results, we derived corrected values for all of these markers by employing HPT. Among these values, the corrected GA (=GA+0.124×HPT-12.4) exhibited the strongest correlation with the average BG (r=0.85) and the minimal rate of abnormal values (12%). Thus, corrected GA has the potential to serve as a readily available glycemic control marker for patients with chronic liver disease.View full abstractDownload PDF (1542K) -
Takenori Sakai, Hisaka Minami, Masaaki Tamaru, Bunzou Matsuura, Hiroak ...1997 Volume 40 Issue 1 Pages 25-28
Published: January 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA missense mutation in the glucagon receptor gene causing a Gly to Ser change at codon 40 (Gly40→Ser) has been reported to be associated with non-insulin-dependent diabetes mellitus (NIDDM) in a French population. To investigate the association of this mutation with NIDDM in Japanese, we screened 145 unrelated NIDDM patients and 265 control subjects for the presense of the Gly40→Ser mutation by polymerase chain reaction restriction fragment length polymorphism analysis. None of the Japanese NIDDM patients and control subjects enrolled in this study had this mutation. Our results suggest that the Gly40 →Ser mutation does not play an important role in the pathogenesis of NIDDM in the Japanese populationView full abstractDownload PDF (2077K) -
Shinichiro Takayama, Yoshiastu Takahashi, Takeshi Ito, Yasue Omori1997 Volume 40 Issue 1 Pages 29-33
Published: January 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSCase 1: A 46-year-old woman with NIDDM was admitted to our hospital for glycemic control. On laboratory examinations, she showed a high plasma CA19-9 concentration (462 U/ml) and Lewis type a+, b-. There were no abnormalities on abdominal echography, abdominal CT scan and ERCP. Decreases in plasma CA19-9 paralleled the HbAic level for 3 years. Case 2: A 42-year-old woman with NIDDM was admitted to our hospital for glycemic control. On laboratory examinations, sheshowedahighplasmaCA19-9uoncentration (240 U/ml) and Lewis type a+, b-. There were no abnormalities or abdominal echography, abdominal CTscan and ERCP. Decreases in plasma CA19-9 paralleled the HbA1c level for 3 years. There have been no reports, to our Knowledge, of NIDDM associated with such high plasma CA19-9 levels as those seen in these two cases, neither of whom had pancreatic carcinoma. We suggest that hyperglycemia with diabetes may play a role in the high levels of CA19-9 associated with blood type Lewis a+b-.View full abstractDownload PDF (617K) -
1997 Volume 40 Issue 1 Pages 35-54
Published: January 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (4692K)
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