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Volume 32, Issue 6
Displaying 1-7 of 7 articles from this issue
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Tomoko Kohama, Yasue Omori, Satomi Minei, Meimi Shimizu, Rima Akihisa, ...1989 Volume 32 Issue 6 Pages 367-372
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe studied the usefulness of serum fructosamine in evaluating the control of pregnant diabetics whose abnormal metabolism must be normalized during pregnancy.
Serum fructosamine was measured in 60 pregnant diabetics, as were HbA1 and blood glucose, every 2 or 4 weeks. Fructosamine changes in ten pregnant diabetics were evaluated postprandially. Controls were 42 normal non-pregnant women, 107 normal pregnant women (based on their 75-g GTT) and 183 non-pregnant diabetic women. The fasting fructosamine level was 24.4±1.6 μmol/g-protein (M±S. D.) in normal women. In normal pregnant women, fructosamine was 25.1±2.1 μmol/g-protein during the first trimester, which decreased slightly during the second trimester: but there were no significant changes during pregnancy. In pregnant diabetics, fructosamine levels were high during the first trimester, and decreased during the second and third trimesters in response to diabetic therapy.
Fructosamine in normalized faster than HbA1 according to diabetic control, because it has a shorter half life than HbA1·Moreover fructosamine does not depend on the postprandial hyperglycemia, 75-g GTT or the exogenous administration of glucose experimentally. Those findings suggest that fructosamine can serve as a useful index of control in pregnant diabetics.View full abstractDownload PDF (1012K) -
Nanami Abe, Atunori Kashiwagi, Yasuo Kida, Yoshihiko Nishio, Mitsuaki ...1989 Volume 32 Issue 6 Pages 373-378
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to evaluate the factor precipitating chronic congestive heart failure (CHF) in diabetics, we compared the clinical charactaristics of 26 cardiomegalic diabetics with CHF (CHF group) with those of 30 cardiomegalic diabetics without CHF (CM group) among 606 diabetic patients who were admitted to the hospital of Shiga University of Medical Science.
There was no difference in age, duration of diabetes, body mass index, or fasting plasma glucose and serum cholesterol levels between the 2 groups.
However the CHF group had a significantly (p<0.005) higher (62%) frequency of nephropathy with increasing serum creatinine level (1.8±0.3mg/dl) and urinary protein excretion (2.6±1.2g/day) than the CM group. Furthemore the CHF group had a significantly (p<0.005) higher frequency of anemia and hypoproteinemia than the CM group.
The prevalence of CHF in female diabetics (7.4%) was 4.1-fold greater (p<0.005) than that in male diabetics (1.8%). The specific factor precipitating CHF in female diabetics is still unknown.View full abstractDownload PDF (2818K) -
Koji Nakanishi, Tetsuro Kobayashi, Tadao Sugimoto, Toshio Murase, Kino ...1989 Volume 32 Issue 6 Pages 379-384
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe predictive value of insulin autoantibodies (IAA) was determined prospectively in 58 non-insulindependent diabetics (NIDD) with and without IAA. The longitudinal changes in serum C-peptide (CPR) responses to a 100-g oral glucose tolerance test (OGTT) as well as IAA and islet cell antibodies (ICA) in these subjects were followed up to 84 months (mean 38 months).
Based on the positivity for IAA and ICA during the study, the subjects were divided into the following 4 groups: 1) persistently IAA-and ICA-positive subjects (Group 1, n=7); 2) persistently IAA-negative and ICA-positive subjects (Group 2, n=18); 3) persistently IAA-positive and ICA-negative subjects (Group 3; n=3); 4) persistently IAA-and ICA-negative subjects (Group 4, n=30).
In Group 1 subjects the serum CPR to the OGTT decreased significantly during the follow-up study (p<0.01), while in the remaining three groups, the response did not show any significant change. Blood glucose levels during the OGTT in group 1 increased (p<0.01), while the values in the remaining groups showed no significant change. Four out of the 7 subjects in Group 1 and 3 out of the 18 in Group 2 progressed slowly to the insulin-dependent state (p=0.07 Group 1 vs. Group 2). None of the subjects in Group 3 or Group 4 progressed to the insulin-dependent state (p=0.01 Group 1 vs. Group 4).
These results suggest that IAA increase the predictive value of ICA for further progression of beta-cell dysfunction in the non-insulin-dependent stage of Type 1 diabetes.View full abstractDownload PDF (881K) -
Effect of High Concentration of Glucose on the SFMC LevelMasaaki Kameyama, Koji Kuboki, Hisako Kameyama1989 Volume 32 Issue 6 Pages 385-390
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo clarify whether glycation of fibrinogen (Fbg) and fibronectin (Fn) affects the formation of soluble fibrin monomer complexes (SFMC), a study was carried out in vitro. Fbg and Fn purified from human plasma were incubated for 4 days at 37°C in phosphate buffered saline, pH 7.4, containing 500 mM glucose. Four different samples were tested. Sample A was composed of glycated Fbg and Fn B, of non-glycated Fbg and glycated Fn C, of glycated Fbg and non-glycated Fn D, of non-glycated Fbg and Fn. Equal amounts of thrombin were added to each sample. The concentrations of SFMC produced by thrombin were measured and the ratios of Fn to fibrin (ogen) in the complex were estimated by SDS-PAGE. The highest level of SFMC was found in A, and the lowest concentration in D. In contrast, D showed the highest ratio of Fn to fibrin (ogen) and A showed the lowest ratio. From these results, SFMC generated in A seemed to have more fibrin and less Fn than the other three samples. The high SFMC level in A may be caused by the increase in it's fibrin content. Therefore, fibrin-rich and Fn-poor SFMC such as A was thought to have a decreased solubility of fibrin.
It is concluded that glycation of Fbg and Fn resulted in elevation of the SFMC level by formation of fibrin-rich and Fn-poor SFMC. This SFMC may precipitate fibrin on the vessel wall in vivo more easily.View full abstractDownload PDF (4088K) -
Toshimi Asahi, Seiji Ohgaku, Tasuku Sawa, Hisao Morioka, Saburo Yano, ...1989 Volume 32 Issue 6 Pages 391-398
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of a 28-year old insulin-dependent diabetes female with 13 years duration. She had repeated cardiorespiratory arrests which were preceded by respiratory arrest. She had the diabetic complications of retinopathy (Scott IV), nephropathy (nephrotic syndrome), and neuropathy, She presented a severe autonomic neuropathy: orthostatic hypotension, reduction in CVR-R, decreased changes in heart rate during deep-breathing and after standing. After ruling out cardiogenic arrest such as that in Adams-Stokes syndrome, sleep apnea syndrome, and amyloid neuropathy, we finally reached the diagnosis of cardiorespiratory arrest resulting from diabetic autonomic neuropathy. In further study, she demonstated hypoxic depression in ventilatory responses to isocapnic progressive hypoxia using CHEMO TEST 531
This is the ninth reported case of cardiorespiratory arrest secondary to diabetic autonomic neuropathy, and the second in which hypoxic depression has been confirmed in Japan.View full abstractDownload PDF (1177K) -
Hiroshi Hasegawa, Makoto Otsuki, Makoto Koide, Yoshinori Okabayashi, T ...1989 Volume 32 Issue 6 Pages 399-401
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe oral administration of glucose results in a considerably greater increase in insulin secretion than intravenous administration. The higher insulin secretion after oral glucose is called the incretin effect and has been ascribed to stimulation of insulin secretion by gastrointestinal hormones. Recent studies in experimental animals have suggested that cholecystokinin (CCK) modulates the secretory activity of the pancreatic B-cell as well as regulating exocrine pancreatic secretion and gall bladder contraction. However, little is known about the effect of CCK on insulin release in humans. Moreover, it is not clear whether CCK is released after glucose ingestion. Until recently the ability to study CCK secretion has been hampered by the lack of a specific and sensitive assay for CCK. In this study, by using a sensitive and specific bioassay based on amylase release from isolated rat pancreatic acini, we measured plasma CCK bioactivity after oral glucose (75g) administration in normal subjects and patients with non-insulin dependent diabetes mellitus (NIDDM). In both the controls and NIDDM patients, ingestion of glucose caused a 4-to 5-fold increase in plasma CCK bioactivity prior to the increase in blood glucose and serum insulin levels. The present observatios suggest the possibility that CCK modulates insulin release in humans.View full abstractDownload PDF (496K) -
1989 Volume 32 Issue 6 Pages 403-433
Published: June 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (8009K)
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