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Volume 45, Issue 12
Displaying 1-14 of 14 articles from this issue
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[in Japanese]2002 Volume 45 Issue 12 Pages 839
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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[in Japanese]2002 Volume 45 Issue 12 Pages 840-842
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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[in Japanese]2002 Volume 45 Issue 12 Pages 843-845
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]2002 Volume 45 Issue 12 Pages 847-850
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]2002 Volume 45 Issue 12 Pages 851-854
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 45 Issue 12 Pages 855-859
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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Kanemi Aoki, Matsuo Taniyama, Fumiko Otsuka, Ryu Takahashi, Tsutomu Sa ...2002 Volume 45 Issue 12 Pages 861-866
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe report 4 patients with abrupt-onset type 1 diabetes mellitus characterized by the absence of diabetesrelated autoantibodies similar to the subtype reported by Imagawa et al.Hemoglobin Aic ranged from 5.0% to 7.9%. Urinary excretion of C-peptide was lower than 5 μg/day and the serum concentration of C-peptide after glucagon injection was lower than 0.3 ng/ml in all 4 patients, 3 of whom tested negative for glutamic acid decarboxylase (GAD) antibodies.GAD antibody was slightly elevated in the other patient, but this was not considered significant.Islet-cell antibodies were not detected in any of the 3 patients tested. These patients did not have significantly elevated serum amylase typically seen in fulminant type 1 diabetes mellitus. Two of our patients had signs of upper respiratory viral infection shortly before diabetes onset. All 4 patients had HLA-A 24 and DR 4 and/or DR 9. Our findings suggest that fulminant type 1 diabetes mellitus is not necessarily accompanied by elevated serum pancreatic enzyme and that HLA-A 24 may play a role in abrupt-onset type 1 diabetes mellitus characterized by the absence of diabetes-related autoantibodies.View full abstractDownload PDF (1038K) -
prospective randomized controlled group study for 1 year using a unique pedometerMasahiro Yokochi, Mitsuro Niinomi, Yasuhisa Kato, Yuko Yanbe, Kazuyo T ...2002 Volume 45 Issue 12 Pages 867-874
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo evaluate the effectiveness of long-term intervention in physical activity for daily exercise and diabetic glucose control, we used a unique pedometer that memorizes caloric consumption by physical movement, the total number of steps, and intensity of physical movement for 42 days.Intervention was held showing daily profile graphic data on walking for a month.
The number of steps in the intervention group was maintained at more than 13000 steps per day at1 year after discharge.In nonintervention group, it decreased gradually after discharge, and it was 8845 steps 1year after.
HbAic of the intervention group decreased from 9.2% at admission to 6.1% at 5 months after discharge and it was maintained for 1 year thereafter. Although HbAic of the nonintervention group improved from 9.2% to 7.0% 3 months later, it was significantly high (7.6%) at 1 year after discharge.
The continuation of intervention in physical activity was effective for maintaining habitual exercise and improving metabolic changes.Exercise is a major therapeutic strategy in Type 2 diabetics and “walking” is widely recommended as an easy, safe aerobic exercise.View full abstractDownload PDF (1369K) -
Satoko Maruyama, Munehiro Miyamae, Shinichiro Takayama, Shinichi Teno, ...2002 Volume 45 Issue 12 Pages 875-879
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 74-year-old woman with a 20-ear history of type 2 diabetes mellitus admitted for back pain, fever, and a diabetic ulcer of the first right toe was found in abdominal computed tomography (CT) to have an abscess in the bilateral psoas muscle.She also reported pain in her left elbow, from which pus was aspirated.The bilateral psoas abscess was incised under general anesthesia, the left elbow was drained surgically, and the first and second toes were amputed, but she remained febrile and reported increasing pain and swelling of the buttocks and bilateral thighs.CT at these sites showed fluid collection, so the gluteal muscles and bilateral thighs were incised and drained.Postoperatively, her symptoms and clinical signs improved, and she was discharged after rehabilitation, walking with a prosthesis.
Pyomyositis should be considered in the differential diagnosis of any immunocompromised subjects with myalgia and fever.We hope that an increased awareness of pyomyositis will improve management of this disease.View full abstractDownload PDF (1268K) -
Nobuki Hayakawa, Masaki Makino, Hiroaki Kakizawa, Shigeo Imamura, Keik ...2002 Volume 45 Issue 12 Pages 881-887
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA-33-year-old woman who suddenly developed excessive thirst on March 31, 2001, and was admitted on April 2, 2001, due to an impending abortion lost consciousness after the abortion and was transferred to our hospital. Her blood glucose was 789 mg/dl with severe metabolic acidosis, pH 7.006, and positive serum and urinary ketone bodies, consistent with diabetic ketoacidosis.Her HbAic was close to normal (6.1%), while urinary C-peptide was very low (1.2μg/day).Serum concentrations of amylase, lipase, and elastase 1 were elevated.The results of a glucagon loading test showed impaired insulin secretion.Diabetes-related autoantibodies including anti-GAD-antibody, anti-IA-2-antibody, and ICA were all negative.Her HLA type was A 2, A 24 (9), B 61 (40), B 51 (5), DR 2, DR 8, DQ 1, and DQ 4.The onset of type 1 diabetes during pregnancy has mostly been reported during the 2nd and 3rd trimesters and is rare in early pregnancy.Fulminant type 1 diabetes has been proposed characterized by near-normal HbA1c despite diabetic ketoacidosis and rapid loss of insulin secretion.Here, we report the case of a pregnant woman who developed typical fulminant type 1 diabetes as early as 7 weeks into gestation.View full abstractDownload PDF (1235K) -
Naoichi Sato, Naoki Nakashima, Asako Konomi, Kunihisa Kobayashi, Toyos ...2002 Volume 45 Issue 12 Pages 889-894
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 51-year-old man diagnosed with Cowden disease based on multiple facial trichilemmoma, oral mucosal papillomatosis, palmo-planter keratosis and muliple hamartomatous polyps in the gastrointestinal tract had had a heterozygous flameshift mutation identified in his PTEN gene (4 base insertion after codon 221), believed to be responsible for the disease.We examined his insulin sensitivity.His fasting blood glucose was 92μg/dl while his fasting immunoreactive insulin (IR) was1.3μU/ml (HOMA-R0.30) and C peptide immunoreactivity below 0.1ng/ml. An euglycemic hyperinsulinemic clamp study showed that mean glucose infusion, which mainly reflects insulin sensitivity in the skeletal muscle, rose to 14.1mg/kg/min (normal: almost 8.0-10.0 mg/kg/min) when serum IR was 70.3μU/ml at a constant insulin infusion of 1.5 mU/kg/min.The portal glucose uptake to the liver was 79.9, which also increased compared to normal subjects (approximately 30-40%). PTEN is a lipid phosphatase against phosphatidylinositol 3, 4, 5-triphosphate and may negatively regulate insulin singaling in vitro and in vivo. This case suggests that PTEN protein may play an important role on insulin sensitivity and glucose homeostasis in the human being.View full abstractDownload PDF (1860K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 45 Issue 12 Pages 895-898
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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controlled Normotensive Diabetic Patients without Perindopril TreatmentSeiho Nagafuchi, Shiori Kondo, Yoshikazu Murakami, Etsushi Kounoue, Ta ...2002 Volume 45 Issue 12 Pages 899-903
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo determine the benefit of periondopril, an angiotensin-converting enzyme inhibitor (ACE inhibitor), on early diabetic nephropathy in patients with mild hypertension, we conducted a 1-year follow-up study monitoring blood pressure, HbA1c, and urinary albumin in 8 patients with mild hypertension who received perindopril treatment, and compared these results to those for 9 well-controlled diabetic patients with normotension and microalbuminuria not receiving perindopril treatment.One year later, all 8 patients receiving perindopril showed improved microalbuminuria, while only 3 of the 9 patients with normotension showed reduced microalbuminuria (P=0.0067).Urinary albumin increased from 71.8±45.3 mg/g·Cr to 96.9±62.7mg/g·Cr (p=0.261) in patients with normotension.In contrast, in patients with mild hypertension receiveing perindopril, urinary albumin decreased from 98.3±57.7 mg/g·Cr to 43.4±30.0 mg/g·Cr (P=0.013). Patients with mild hypertension receiving perindopril showed significantly reduced microalbuminuria compared to normotensive patients not receiving perindopril (P=0.010).View full abstractDownload PDF (810K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 45 Issue 12 Pages 905-910
Published: December 30, 2002
Released on J-STAGE: March 02, 2011
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