Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 59, Issue 3
Displaying 1-4 of 4 articles from this issue
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Original Articles
Pathophysiology, Metabolic Abnormalities, Complications
  • Comparison of Operative Procedures of Partial Pancreatectomy by Postoperative Insulin Secretory Capacity and Glucose Intolerance
    Tsuguka Shiwa, Masayasu Yoneda, Haruya Ohno, Kazuhiro Kobuke, Kenichir ...
    2016 Volume 59 Issue 3 Pages 149-155
    Published: March 30, 2016
    Released on J-STAGE: March 30, 2016
    DOIhttps://doi.org/10.11213/tonyobyo.59.149
    JOURNAL FREE ACCESS
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    We studied the effects of pancreatic resection on the postoperative β-cell function and glucose intolerance in relation to the pancreatic volume (PV). Eighteen patients undergoing pancreaticoduodenectomy (PD) and 18 patients undergoing distal pancreatectomy (DP) were enrolled. The β-cell function was assessed using C-peptide values obtained from a glucagon stimulation test. The PVs were measured with a computed tomography scan. There was no significant difference in the preoperative PV, β-cell function or diabetes mellitus prevalence between the two groups. The postoperative C-peptide levels were significantly correlated with the remaining PV according to pancreatectomy. However, the β-cell function to the remaining PV ratio in DP was significantly lower than that in PD. Postoperative diabetes mellitus (PODM) in DP was significantly higher than that in PD at 3 months after surgery (PD 33.3 % vs. DP 72.2 %). New-onset PODM in DP was also significantly higher than that in PD at 1 year after surgery (PD 14.3 % vs. DP 63.6 %). The postoperative β-cell function to the remaining PV ratio in DP was significantly lower than that in PD. Patients undergoing DP may be at a higher risk of PODM than undergoing PD. These results suggest that a follow-up focusing on the development of PODM should be necessary in patients undergoing DP.
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  • Endothelial Function in Diabetic Patients: Estimation by RHI (Reactive Hyperemia Peripheral Arterial Tonometry Index)
    Yuko Murata, Yoshiki Kadoya, Syoichi Yamada, Machi Furuta, Tokio Sanke
    2016 Volume 59 Issue 3 Pages 156-162
    Published: March 30, 2016
    Released on J-STAGE: March 30, 2016
    DOIhttps://doi.org/10.11213/tonyobyo.59.156
    JOURNAL FREE ACCESS
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    The endothelial function was estimated in diabetic patients (N=189) using a dedicated instrument Endo-PAD 2000 and expressed as the reactive hyperemia peripheral arterial tonometry index (RHI). The mean RHI of the overall cohort was 1.56±0.37, and 68.3 % of the patients were under 1.67, the lower limit of normal subjects. A multiple regression analysis indicated that the RHI was significantly correlated with the systolic blood pressure at examination (P<0.001) and the presence of peripheral arterial disease (PAD) estimated by the ankle brachial pressure index (<0.9). A multiple comparison test adjusted by the systolic blood pressure also showed that the RHI of patients with PAD was significantly lower than that of patients without macroangiopathy. The RHI was also significantly correlated with urine albumin excretion (ACR) in select patients with ACR less than 150 mg/gCr. These data indicate that the RHI estimated by the Endo-PAD 2000 is largely affected by the systolic blood pressure at examination and suggest that the RHI is correlated with the presence of PAD and mild albuminuria.
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Case Report
Report of the Committee
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