VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 39, Issue 5

Displaying 1-37 of 37 articles from this issue

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RELATIONSHIP OF BIOTIN TO BACTERIAL SPORULATION (I) INHIBITION OF SPORULATION BY α-PICOLINIC ACID

Toshio NIIMURA

Article type: Article
1969 Volume 39 Issue 5 Pages 301-304
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_301

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Bacillus megaterium was incubated in the presence of α-picolinic acid, a specific antisporogenic agent, and the relationship of biotin formation to sporulation was studied. α-Picolinic acid delayed the formation of biotin, and the sporulation was performed after the intracellular biotin reached the maximal level. It seems that the sporulation was prevented until that time. While the sporulation was proceeding, biotin was secreted only as the free-form, and also the bound-form was observed in the sporulating-medium after the mature free spores were liberated from the cells.

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RELATIONSHIP OF BIOTIN TO BACTERIAL SPORULATION (II) EFFECT OF THE AMOUNT OF INTRACELLULAR BIOTIN TO SPORULATING ABILITY

Article type: Article
1969 Volume 39 Issue 5 Pages 304-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_304

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RELATIONSHIP OF BIOTIN TO BACTERIAL SPORULATION (II) EFFECT OF THE AMOUNT OF INTRACELLULAR BIOTIN TO SPORULATING ABILITY

Toshio NIIMURA

Article type: Article
1969 Volume 39 Issue 5 Pages 305-309
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_305

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The sporulating ability of Bacillus megaterium was investigated in both biotin-dependent strain and biotin-independent strain by the active culture method, and by the technique of endotrophic sporulation. The biotin-restricted cells were prepared by incubating in the desthiobiotin-limiting medium for the biotin-dependent strain and, by incubating in the presence of ethionine for the biotin-independent strain. Under the biotin-deficient condition, the biotin-dependent strain accumulated abnormally a large amount of lipid inclusions in the cells, but the sporulation was markedly inhibited. As the amount of intracellular biotin increased, the number of spore formed increased proportionally. When the biotin-restricted cells of both strains were supplied with biotin in the sporulating-medium, the sporulating ability was markedly recovered. It is suggested that biotin is one of the factors which are related to the sporulating ability of cells in the later stages of logarithmic growth phase.

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STUDIES ON THE ABSORPTION OF S-BENZOYLTHIAMINE O-MONOPHOSPHATE (VI) ABSORPTION AND METABOLISM OF THE PHOSPHATE AND BENZOYL GROUPS

Hideyo SHINDO, Koichi OKAMOTO, Eiichi NAKAJIMA, Isao TAKAHASHI

Article type: Article
1969 Volume 39 Issue 5 Pages 310-316
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_310

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Absorption and behaviors of the phosphate and benzoyl groups in S-benzoylthiamine O-monophosphate (BTMP) after the oral administration have been investigated in comparison with those of the thiamine moiety, using ^<32>P, ^3H (benzoyl)-labelled BTMP. After infusion of ^<32>P-BT MP in dog ligated intestinal loop, ^<32>P was found to be absorbed in the blood very rapidly, independent from the thiamine moiety. Blood ^<32>P, ^3H and thiamine concentration of rats orally given the double-labelled BTMP showed that, i) ^<32>P, after a fast rise and a decline, kept the highest level for over 24 hours, being incorporated in red cells, ii) ^3H level, after a fast rise, declined most rapidly, being almost negligible after 2 hours, and iii) thiamine showed an intermediate features of these two. Urinary excretion in 24 hours was ^3H (86%)>thiamine(38%)>^<32>P (12%), indicating that the phosphate group remained in the body for the longest period, while the benzoyl group for the shortest to be excreted in urine, possibly, as hippuric acid. Whole body autoradiography of ^<32>P-BTMP in mice showed that the highest activity was concentrated in bone and to a less extent in liver, the former being kept for over 120 hours. There was found no significant difference in the absorption and behaviors of radio-phosphorus between the administration of ^<32>P-BTMP and ^<32>P-inorganic phosphate. These results confirmed the mechanism of absorption of BTMP that after dephosphorylation of BTMP at the mucosal surface of intestine, S-benzoylthiamine is absorbed in the blood.

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THE CONVERSION OF THIOCTAMIDE TO THIOCTIC ACID IN BIOLOGICAL SYSTEM (II) ENZYMATIC HYDROLYSIS OF THIOCTAMIDE AND ITS DERIVATIVES

Junitsu SAITO

Article type: Article
1969 Volume 39 Issue 5 Pages 317-322
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_317

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Hydrolysis of thioctamide and its related compounds in rabbit and rat were investigated in vivo and in vitro by qualitative and quantitative analyses. The enzymes, which hydrolyze thioctamide, N-lipoylglutamic acid, N-lipoyl methionine, N^1-lypoyl-N^2-isonicotinoylhydrazine, methyldihydrolipoate were found in several tissues, in which the high specific activity was observed in liver and kidney. The enzyme was found in the particulate fraction of liver. It was also observed that trypsin, pepsin, pancreatin, Takadiastase B and lipase were not able to hydrolyze thioctamide.

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STUDIES ON VITAMIN B_1 AND RELATED COMPOUNDS (CVIII) SYNTHESES OF S-(α-ACYLOXYALKYL) THIAMINE DERIVATIVES

Yoshikazu OKA, Eiko IMAMIYA, Katsutada MASUDA

Article type: Article
1969 Volume 39 Issue 5 Pages 323-329
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_323

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Some attemps were made to synthesize S-(α-acyloxyalkyl) thiamine derivatives expecting thiamine activity. S-Alkylthiamines were oxidized with hydrogen peroxide in acetic acid to afford S-alkylthiamine sulfoxides (V-VII). The sulfoxides were found to be very inert to the attempted Pummerer rearrangement under ordinary conditions. Thus treatments of them with acetic anhydride gave S-alkyl-O-acetylthiamine sulfoxides (VIII, IX) under room temperature and S-alkyl-O, N-diacetylthiamine sulfoxides (X, XI) at 50-70℃. Treatments of V and VI, however, with acetic anhydride under more severe conditions, at 100-120℃, they underwent Pummerer rearangement to give XIII and XIV in poor yields. Some other S-(α-acyloxyalkyl) thiamine derivatives (XV-XVII) were also obtained by the reaction of the thiol-form salt of thiamine and l-benzoyloxyalkylchloride. All these derivatives (XIII-XVII) were found to be easily hydrolyzed to thiamine with hydrochloric acid and to show thiamine activities in rats.

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COMPLEX COMPOUNDS OF THIAMINE AND HEAVY-METALS (V) A MODEL STUDY OF THE BEHAVIOR OF THIAMINE IN METAL-POISONING (1) THE MECHANISM OF DECOMPOSITION OF THIAMINE AND ITS MEANING IN COPPER POISONING

Akira TANAKA

Article type: Article
1969 Volume 39 Issue 5 Pages 330-336
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_330

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A new type of thiamine-copper complex, previously reported, shows a thiamine decomposing power nearly corresponding to equimolar concentration of copper ion. On this basis, an assumptive scheme on the degradation mechanism of thiamine by copper ion is presented. That is to say, in a thiamine solution contaminated with Cu^<2+>, alternative formation and degradation of the thiamine-copper complexes may occur, and this may be the cause of the gradual decomposition of thiamine by Cu^<2+>. Based on the results of spectrophotometrical studies, the practical significance of the thiamine-heavy metal complexes is discussed, e. g., possible mechanisms leading to avitaminosis in metal-poisoning are speculated : viz., the state of thiamine deficiency may be caused by the decomposition of thiamine by copper ion as well as by thiamine fixing in thiol type by the formation of mercaptide complexes with Ag^+, Cu^<2+>, and Hg^<2+>.

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THE EFFECT OF THIAMINE DERIVATIVE ON ISOLATED GUINEA PIG'S ATRIUM THE ACTION OF THIAMINE TETRAHYDROFURFURYL DISULFIDE AND PYRUVIC ACID

Hideo SHINOZAKI

Article type: Article
1969 Volume 39 Issue 5 Pages 337-340
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_337

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Thiamine tetrahydrofurfuryldisulfide (TTFD), a derivative of thiamine, showed a positive inotropic action on an isolated guinea pig's atrium. It was found that hydroxyethylthiamine-monophosphate (HETP) is formed by combination of thiamine which is distributed in large quantities to an isolated atrium to which TTFD was added and pyruvic acid absorbed excessively. It was suggested that the pharmacological actions of TTFD are related to the formation of HETP.

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 341-342
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_341

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 342-343
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_342

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 343-344
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_343

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 344-346
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_344

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 346-347
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_346

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 347-348
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_347

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 348-349
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_348

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 350-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_350_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
1969 Volume 39 Issue 5 Pages 350-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_350_2

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[title in Japanese]

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Article type: Article
1969 Volume 39 Issue 5 Pages 351-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_351_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 351-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_351_2

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[title in Japanese]

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Article type: Article
1969 Volume 39 Issue 5 Pages 351-352
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_351_3

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[title in Japanese]

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Article type: Article
1969 Volume 39 Issue 5 Pages 352-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_352_1

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[title in Japanese]

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Article type: Article
1969 Volume 39 Issue 5 Pages 352-353
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_352_2

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[title in Japanese]

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Article type: Article
1969 Volume 39 Issue 5 Pages 353-354
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_353

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[title in Japanese]

[in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 354-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_354_1

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Article type: Article
1969 Volume 39 Issue 5 Pages 354-355
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_354_2

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Article type: Article
1969 Volume 39 Issue 5 Pages 356-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_356_1

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Article type: Article
1969 Volume 39 Issue 5 Pages 356-357
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_356_2

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Article type: Article
1969 Volume 39 Issue 5 Pages 357-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_357

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Article type: Article
1969 Volume 39 Issue 5 Pages 358-
Published: May 25, 1969
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DOIhttps://doi.org/10.20632/vso.39.5_358_1

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Article type: Article
1969 Volume 39 Issue 5 Pages 358-359
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_358_2

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Article type: Article
1969 Volume 39 Issue 5 Pages 359-360
Published: May 25, 1969
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DOIhttps://doi.org/10.20632/vso.39.5_359

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Article type: Article
1969 Volume 39 Issue 5 Pages 360-361
Published: May 25, 1969
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DOIhttps://doi.org/10.20632/vso.39.5_360

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1969 Volume 39 Issue 5 Pages 361-
Published: May 25, 1969
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DOIhttps://doi.org/10.20632/vso.39.5_361_1

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Article type: Article
1969 Volume 39 Issue 5 Pages 361-362
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_361_2

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Article type: Article
1969 Volume 39 Issue 5 Pages 364-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_364

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[title in Japanese]

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Article type: Article
1969 Volume 39 Issue 5 Pages 365-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_365_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
1969 Volume 39 Issue 5 Pages 365-
Published: May 25, 1969
Released on J-STAGE: February 17, 2018

DOIhttps://doi.org/10.20632/vso.39.5_365_2

JOURNAL FREE ACCESS

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