Oral lichen planus is an intractable inflammatory muco-cutaneous disease. Although much research has been carried out on the pathogenetic mechanism and treatment methods, and a vast amount of knowledge has been obtained, this disease unfortunately has not been yet elucidated and suppressed. The OLP Committee of the Japanese Association of Oral Medicine was established with the aim of continuing and further developing the work of the former Lichen Planus Working Group, which acted jointly with the Japanese Society of Oral Pathology over the last decade. In this review, this Committee will collect and present as much of the currently available knowledge regarding oral lichen planus as possible, and also recommend the direction of research development in the future.

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With the improvement of therapy outcomes for malignant neoplasms, fertility preservation is increasingly being considered for the adolescent and young adult （AYA） generation between the ages of 15 and 39.
The annual number of patients with malignant neoplasms in Japan is one million, of which 20,000 are in the AYA generation and 14,000 （67％） are women. As fertility preservation therapies, surgery and drugs are available for early gynecological cancers. In the case of cervical cancer, a prophylactic vaccine against human papilloma virus is effective. For non-gynecological cancers, the freezing of fertilized eggs, unfertilized eggs, and ovarian tissue prior to therapy is an option. The most common malignancies detected during pregnancy are breast, thyroid and cervical cancers, and leukemia. Anticancer drugs can be administered after 14 weeks of gestation, but preferably after 17 weeks, since the eyes, hematopoietic system, and central nervous system are more susceptible to damage from anticancer drugs.
In fertility preservation therapy, multidisciplinary collaboration is essential to explain to the patient in a short period of time and to facilitate prompt decision-making.

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In recent years, multiple chemical sensitivity and sick building syndrome have become social problems. Formaldehyde products, which have conventionally been used in dentistry, have been identified as the most significant cause of chemical sensitivity and sick building syndrome. Currently, there is no legal enforcement of formaldehyde control, although the government, schools, and professional associations are pushing for stricter regulation of formaldehyde. In addition, the general public and medical professionals should be further educated about the actual damage caused by formaldehyde and the health problems it can cause.
This paper reports on the biohazardous effects of formaldehyde products in dentistry, with the aims of informing dental professionals of the dangers of formaldehyde products and eliminating their use in dental clinics.

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Chronic inflammatory diseases develop anemia of chronic disease （ACD） with specific abnormalities in iron metabolism. Chronic inflammation triggers release of inflammatory cytokines, which stimulate hepcidin expression in the liver.　Increased hepcidin production leads to a decrease in serum iron, resulting in anemia. Medication-related osteonecrosis of the jaw （MRONJ） promotes chronic inflammation due to osteomyelitis. We report two cases of anemia attributable to MRONJ-induced chronic inflammation. Diagnosis and treatment must focus not only on anemia secondary to poor oral intake, but it is also important to consider ACD in patients with MRONJ.

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Bone metastases are common in patients with prostate cancer, but they are mainly located in the lumbar spine, thoracic spine, and pelvis; metastases to the head and neck region are extremely rare. In this report, we describe a case of mandibular metastasis of prostate cancer in a patient who was referred to our department with a complaint of mandibular swelling. Histopathological examination revealed immunostaining, CK7 and CK20 were negative, PSA, a prostate cancer marker, was partially positive, and p504S, NKX3.1 was strongly positive in the nucleus. For these reasons, he was diagnosed with bone metastasis of prostate cancer.

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Here we report a case of perforation of the small intestine by metastasis of cancer of the upper gingiva. The patient was an 86-years-old man who had squamous cell carcinoma of the upper gingiva. The patient enforced partial maxillary resection. And abdominal pain during Radiation therapy. A CT scan taken for the purpose of close examination revealed confirming perforation of the gastrointestinal tract. Surgery was performed immediately. Peritoneal perforation and peritoneal dissemination due to a small intestine tumor were observed. Microscopic findings at this site confirmed a diagnosis of metastatic squamous cell carcinoma in the small intestine from the upper gingiva. If gastrointestinal symptoms appear in a patient with advanced oral cancer, a differential diagnosis of metastasis to the gastrointestinal tract should be kept in mind.

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