A seven-month-old male Borzoi dog showing abnormal walking with rigidity and pain in the forelimbs and staggering of the hind limbs was brought to our clinic. Although no abnormalities were noted in blood tests or X-rays, incision biopsy of the musculus sartorius in the left hind limbs revealed extensive myopathic atrophy with myofibrils of varying sizes, and partial degeneration and necrosis of the myofibrils.
The dog gradually became unable to walk and was euthanized 48 days after the first visit at the owner's request. The owner consented to an autopsy because one of the dog's siblings had previously shown similar unfavorable symptoms and died suddenly. For laboratory testing, we could obtain only the sciatic nerves and muscle samples from the triceps brachii, biceps femoris, pectorial, diaphragm, and right and left ventricular wall. All muscle samples except for the one from the ventricular wall were found damaged by neurogenic atrophy with large to small lesions of atrophic fibers. In the sciatic nerves, Wallerian-like axonal degeneration typically accompanied by endoneurial fibrosis was observed multifocally. From these findings, the dog was considered to have been suffering from neuropathy. The cause of the disease could not be determined, but the possibility of hereditary neuropathy in this breed should be suspected.
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