This study was conducted to evaluate the results of high-dose-rate superficial brachytherapy (SBT) after keloidectomy in comparison with the results of electron beam radiotherapy (ERT).
Forty-six patients who underwent postoperative SBT for 60 histologically confirmed keloids were evaluated. For SBT, the tube catheter and a spacer 5 mm thick were placed on the skin to match the area of the surgical wound. Dose evaluation points were established 2 mm below the skin surface. Twenty Gray (Gy) was delivered in 4 daily fractions to scars on the anterior chest wall, scapular region, and suprapubic region, while a dose of 15 Gy was delivered in 3 daily fractions to lesions in other areas. Therapeutic outcome was judged in terms of recurrence, control, and side effects. For comparison of the therapeutic effect, 50 patients who underwent ERT for 90 keloids in 2006 were also evaluated.
The two-year recurrence-free rates after SBT and ERT were 84.5%. Two patients suffered grade 1 skin erythema, but no toxicity of grade 2 or higher occurred. Compared with the ERT, there were no statistically significant differences in recurrence-free rate and incidence of adverse reactions between the two treatment groups.
Our results indicate that SBT is effective and safe for preventing recurrence of keloids, and might be a feasible alternative to ERT.
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