A Benzethonium chloride disinfectant solution, Rusnon^® Medical Solution, was examined on its disinfective effect and the following results were obtained.
1. Rusnon^® Medical Solution was equivalent to Hyamine Solution in the inhibition effect on the growth of the test microbes.
2. Rusnon^® Medical Solution, as well as Hyamine Solution, completely inhibited the raising of the growth curve of the test microbes.
3. The microbes adhering to dental instruments were completely annihilated after being immersed in Rusnon^® Medical Solution for 24 hrs.
4. Rusnon^® Medical Solution of practical concentration was effective for 10 days.

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The present study was undertaken to examine the movements of alkaline and acid phosphatase activities in the cultured first lower molar tooth germ radiated by far infrared of YYT-1 and YYT-2.
The right and left molar tooth germs were extracted from neonatal Wistar strain rats, and used as control and experimental groups respectively. These tooth germs were cultured in BGJ_b culture media for 2 days, exchanging the culture medium every other day. The left tooth germs of the experimental group was radiated by YYT-1 and YYT-2 during its culture period. ALPase and ACPase activities were measured after 2 days in culture, using the Kind and King method (1954) .
ALPase activity per μg protein was higher in the experimental group than in the control group after 2 days in culture. ACPase activity per μg protein after 2 days in culture was slightly higher in experimental group than in control group.
From these results, it was suggested that ALPase activity in the cultured first lower molar radiated for infrared rays of YYT-1 and YYT-2 tend to increase after 2 days in culture.

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To evaluate the clinical efficacy, safety and utility of Cefteram pivoxil (CFTM-PI) in treating odontogenic infections such as periodontal infection, pericoronitis and osteitis of jaw, we carried out clinical study with 11 institutes. CFTM-PI was administered to 208 patients for odontogenic infections and the dosage was 300 mg/day or 600 mg/day divided into three doses. The following results were obtained.
1) Committee evaluation of the clinical efficacy gave efficacy rate of 88.1% for all cases. The committee's efficacy rates by diagnosis were 90.2%, 91.1% and 85.1% for periodontal infection, pericoronitis and osteitis of jaw, respectively. The efficacy rate of the 300mg group and 600mg group, as judged by committee were 84.0% and 89.4%, respectively.
2) The attending physicians gave efficacy rate of 83.3% for all cases.
3) By needle aspiration to avoid contaminating from the oral floras, 161 strains were isolated from closed abscesses of 91 patients. The isolation rates of aerobic gram-positive bacteria, aerobic gramnegative bacteria, anaerobic gram-positive bacteria and anaerobic gram-negative bacteria were 43.5% (70/161 strains), 2.5% (4/161), 45.3% (73/161) and 8.7% (14/161), respectively. The bacteriological response was“eradication of bacteria”in 52 cases, “unchange of bacteria”in one, “unknown of bacteria”in 16 and unknown in 22. The eradication rate judged by committee was 75.4%.
4) Side effects were noted in 2 (1.0%) out of 207 cases and the symptom was diarrhea for one and abdominal pain for another. These symptoms were not serious in degree. Abnormal changes in laboratory findings were found in 8 patients and main symptom of them was elevation of transaminase.

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The purpose of this study is to criticize clinically“the standardization of evaluation of analgesics efficiency in toothache”which was executed by Japanese Society of Oral Therapeutics and Pharmacology.
117 patients with toothache and related pain which needed analgesic drug were carried out in this study.
2 Tablets of CALONAL 0 Tab.^® (Showa Yakuhin kako Corp. 200mg acetoaminophen/1 tablet) were each administered without symptomatic intra-oral treatment.
The following results were obtained from this study.
1) Acetoaminophen is effective and safe for relieving toothache and related pain. 83% of experimental persons were obtained effective analgesics result.
2) Side effect repoted in 3 of 117 cases (0.3%) : such as stomachache, drawsiness and dizziness. However, latter two cases were considered that there were no relationship with the administrating of CALONAL O Tab.
3) “The standardization of evaluation of analgesics efficiency in toothache”was useful generally to evaluate the analgesic efficiency.

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Many analgesics were developed in the past, and each drug action was evaluated although definite criteria have not been established so far. The method of the criteria has been individually created and carried out by each institute.
Various condition were needed, that were generally excellent and reproductive, in order for an appropriate criteria method of drug action of analgesics to be develeped. These included comparison in the same level with othe drugs and characteristics of the drug had to be grasped without the complexity of the criteria. Although these conditions have not been filled up by convential methods, preparation for the criteria of drug action has been required and consequently in 1984 the following new criterion was established by a committee.
1. The new criterion that the three conditions (inhibition of the pain, rapid action and continuity) being required in analgesics can individually be numerically evaluated, and the evaluations are generally available.
2. This new criterion was actually attempted in several kinds of analgesics differing in properties, and concluded as a criterion method with generally excellent results.

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