It has been considered that supraphysiological doses of vitamin B
6 suppress tumor growth and metastasis in rodents. However, our recent studies have demonstrated that azoxymethane-induced colon tumorigenesis in mice is markedly suppressed by moderate doses of dietary vitamin B
6 similar to the dietary level for humans. The anti-tumorigenetic effect of vitamin B
6 appears to be mediated by suppressing cell proliferation, oxidative stress and nitric oxide (NO) synthesis in the colon. Furthermore, we have found that vitamin B
6 inhibits angiogenesis, which plays an important role in tumor growth and metastasis. Taken together, vitamin B
6 would be an attractive nutrient to prevent the development of colon cancer.
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