Two cases of Turner's syndrome associated with diabetes. mellitus and anti-thyroid antibodies are reported. The first was a 36-yr-old woman who was admitted to our hospital due to short stature and amenorrhea. Her growth and development had been retarded from birth and diabetes mellitus was found at the age of 32. On admission she was 131 cm tall and weighed34 kg. Her chest was shield-shaped with immature breasts. Short metacarpus, black freles andsex-infantism were noticed. Her IQ titer was 70 and anti-thyroid antibodies were detected highly with normal thyroidal function. Her karyotype was 45 XO/46 XXqi. Her HLA type was A₂, A₁₀, B₇, and BW₂₂.
The second case was a 20-yr-old woman who was admitted to our hospital due to short stature and amenorrhea. She was born maturely with a birth weight of 2300 g and her growth had been retarded. Her grand-mother was a diabetic. On admission she was 140 cm tall and weighed 43 kg. She had goiter, a shield-shaped chest, short metacarpus, black freles and sex-infantism. Laboratory data revealed positive anti-thyroid antibodies with normal thyroidal function. Her karyotype was 45 X0. Her HLA type was A₂, B₁₂.
By endocrinological tests, both cases showed diabetic patterns of 100 g-OGTT and high LH & FSH responses to LH-RH tests. However, their TRH tests and Insulin-tolerance tests were normal.
A high incidence of diabetes mellitus and thyroid autoimmunity in Turner's syndrome has been reported in several papers. Based on our cases, the possible significance of an association of diabetes mellitus and autoimmunity with sex chromosomal abnormality is discussed.