We report a case of multiple pyogenic liver abscesses. The patient was a 47-year-old woman with liver abscesses secondary to sigmoid colon cancer. The liver abscesses disappeared after antimicrobial treatment and sigmoidectomy. Histological examination of the resected specimen disclosed circumferential colon cancer and inflammatory adhesion to the bladder and the ileum with formation of small abscesses around the tumor. No evidence of ascending biliary infection, sepsis, nor diverticular disease in the colon were observed. Detailed reports of coloreetal cancer presenting with liver abscesses in the absence of hepatic metastases are extremely rarc. Clinical findings of patients reported to date in the context of literature review are discussed.