Adenoma of the papilla of Vater is considered to be a relatively rare disease. We report a case of the disease without symptoms that we have recently encountered. A 75-year-old woman was found to have an enlargement of the papilla of Vater during an endoscopic examination of the upper digestive tract, and she was admitted to the hospital for thorough examination. Endoscopy of the duodenum revealed an approximately 1cm coarse nodular bulge in the papilla of Vater, which was diagnosed as adenoma by a biopsy. A total extirpation of the papilla of Vater with reconstruction of the papilla was performed. The postoperative course was uneventful. There have been no signs of recurrence as of one year after the operation. It is thought that total extirpation of the region with reconstruction which makes much of patient's QOL is a valuable therapy for the disease if no residual adenoma is left.