HBs抗原持続陽性者の病態と予後に関する研究 特に発端症例の病態と家族内HBs抗原抗体調査成績との関連について

南部 勝司; 上山 洋; 今井 康允; 和田 偉将; 崎田 隆一; 森川 綾子; 佐久間 光史; 前田 裕; 高原 義; 真弓 忠; 津田 文男; 浪久 利彦; 上田 英雄

doi:10.2957/kanzo.23.372

Clinical and pathological observations of HBs Ag carriers

Development of hepatic changes in HBs Ag carriers related to familial occurrence

Masaji NAMBU, Hiroshi UEYAMA, Yasumitsu IMAI, Isho WADA, Ryuichi SAKITA, Ayako MORIKAWA, Koshi SAKUMA, Yutaka MAEDA, Tadashi TAKAHARA, Tadashi MAYUMI, Fumio TSUDA, Toshihiko NAMIHISA, Hideo UEDA

Author information

Masaji NAMBU
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways
Hiroshi UEYAMA
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways
Yasumitsu IMAI
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways
Isho WADA
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways
Ryuichi SAKITA
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways
Ayako MORIKAWA
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways
Koshi SAKUMA
Central Health Institute of Japanese National Railways
Yutaka MAEDA
Central Health Institute of Japanese National Railways
Tadashi TAKAHARA
Central Health Institute of Japanese National Railways
Tadashi MAYUMI
Hepatitis Division, the Tokyo Metropolitan Institute of Medical Science; Immunology division, Jichi Medical School
Fumio TSUDA
Hepatitis Division, the Tokyo Metropolitan Institute of Medical Science; Immunology division, Jichi Medical School
Toshihiko NAMIHISA
Liver Unit, Department of Gastroenterology, Internal Medicine, Juntendo University, School of Medicine
Hideo UEDA
Department of Gastroenterology, Internal Medicine, Central Hospital of Japanese National Railways

JOURNAL FREE ACCESS

1982 Volume 23 Issue 4 Pages 372-378

DOI https://doi.org/10.2957/kanzo.23.372

Details

Abstract

Clinical and pathological observations were performed in 246 subjects with persistent positive serum HBs Ag. They were divided into 3 groups, A: asymptomatic HBs Ag carrier (116 cases), B: HBs Ag carrier with abnormal liver function, firstly observed after long term follow-up study (52 cases), C: HBs Ag carrier with abnormal liver function during long term follow-up study (78 cases). Liver biopsies were performed in 66 cases of these carriers. HBV markers in their families were investigated in 97 subjects among 42 families.
In group A 5 biopsied cases showed minimal histologic change in all, in group B 3 cases showed liver cirrhosis (LC) in 18 cases, and in group C 12 showed LC and 7 showed hepatocellular carcinoma (HCC) in 43 biopsied cases.
Familial occurrence of HBs Ag carrier was significantly low in group A than in group B and C. Five cases with LC and HCC were histologically observed in 11 cases with familial occurrence, and one case showed LC in 19 cases without familial clustering.
Seventeen cases were biopsied twice during 9 years. Histological development were observed in 4 of 5 cases with familial occurrence and 6 of 12 without familial occurrence.
From these results it was suggested that a genetic background was related to the development of liver changes in HBs Ag carriers.

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