We invented a novel simulation-based hands-on training program to educate senior staff physicians for ultrasound-guided central venous catheterization. The new training course consists of the following points: a target vein （internal jugular vein or subclavian vein) can be chosen by trainees, depending on their routine clinical settings; simulators （a box-type simulator with a simple simulated vein or a torso type with an anatomically atypical running simulated vein) can be chosen depending on trainee skill; and training can proceed step by step up to the trainee’s skill level under supervision and outcome-based evaluation by the instructors. The novel simulation training for ultrasound-guided central venous catheterization has been welcomed by the senior staff physicians. We believe the new training may improve their skill and performance in their clinical settings.