We report a case of Vibrio vulnificus infection who survived the complicating septic shock. The patient was a 53 year-old cirrhotic male, who had eaten raw fish on July 19, 2001. He was admitted to a hospital on July 21st with high fever and low blood pressure. He was transferred to our ICU on July 22nd, presenting septic shock. He received ceftazidime (CAZ), minocycline (MINO), and cathecholamines to stabilize circulation, and underwent continuous hemodiafiltration (CHDF) for 4 days for cytokine modulation. Vibrio vulnificus was detected in blood culture obtained at the previous hospital, although he presented no skin lesion when transferred to our ICU. He was transferred to a local hospital on the 12th ICU day after recovery from severe infection and in good general condition. Patients with immunosuppressive disorders such as liver cirrhosis are known to be highly vulnerable to Vibrio vulnificus infection, and it is also reported that infection complicating shock like this case is very difficult for a patient to survive. We believe that early diagnosis and treatment against Vibrio vulnificus and effective management of shock lead to survival of the patient.