Three CAPD cases who maintained increased ultrafiltration volume by long-term and intermittent oral administration of low dose of tranexamic acid

Masaaki Nakayama; Satoru Kuriyama; Naohiko Kato; Hiroshi Hayakawa; Masato Ikeda; Hiroyuki Terawaki; Hiroyasu Yamamoto; Keitarou Yokoyama; Tatsuo Hosoya

doi:10.4009/jsdt.34.1333

Masaaki Nakayama, Satoru Kuriyama, Naohiko Kato, Hiroshi Hayakawa, Masato Ikeda, Hiroyuki Terawaki, Hiroyasu Yamamoto, Keitarou Yokoyama, Tatsuo Hosoya

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JOURNAL FREE ACCESS

2001 Volume 34 Issue 10 Pages 1333-1337

DOI https://doi.org/10.4009/jsdt.34.1333

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Abstract

Accumulated clinical evidence has shown that the oral administration of tranexamic acid (TA) could increase ultrafiltration (UF) volume. However, the clinical consequences of long-term prescription of TA remain unclear. This paper reports three patients who were given low dose TA intermittently (500mg×3days/week) for up to 18 months. During the study period, there were no major adverse effects relating to TA administration, In all cases, a sustained increase in UF volume was observed. In the peritoneal function according to peritoneal equibulation test, there was no change found in one case, while increased permeability was found in two cases. These results may indicate that the long-term intermittent administration of low dose TA is clinically effective in terms of increasing UF volume. Thus, this agent could be used for patients with UF failure instead of a higher glucose level solution. However, the exact effect of TA for the peritoneal function remains unclear, and needs further study.

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