Abstract
Invasive micropapillary salivary duct carcinoma (SDC), a subtype of SDC, is reported to be particularly aggressive.We report a case of invasive micropapillary SDC.A 44-year-old man was referred to us due to swelling of the left parotid gland.Radiological findings showed parotid gland tumor with multiple cervical lymph nodes.Fine needle aspiration cytology (FNA) of the tumor showed ‘Class V, adenocarcinoma suspected’.Extended total parotidectomy with radical neck dissection was performed, and the facial nerve was sacrificed due to adhesion to the tumor.Comedo necrosis and papillary structures were found in the specimen.The papillary structures were absent from the fibrovascular core and had clear spaces around themselves.Immunohistochemical analysis of MUC1 highlighted cells rimming the papillary structures.The tumor was diagnosed as invasive micropapillary SDC.Postoperative chemoradiotherapy was performed, but he died of multiple distant metastasis within one year from the first visit.