Utilizing a non-pharmacist “co-pharmaceutical staff (CPS)” and mechanization and Information and Communication Technology (ICT) is critical for pharmacists to focus on their primary role, i.e., checking effects/side effects after taking medications. If the CPSs efficiency is improved, it can help the pharmacists focus on their primary role. To our knowledge, no prior studies have examined the amount of time CPSs spend on preparing the prescription medicines, and the effect of mechanization and ICT on the efficiency of CPSs. CPSs in Hazama Pharmacy (Osaka, Japan) work together with pharmacists to prepare prescription medicines per the notice (No.0402-1 dated April 2, 2019) from the Ministry of Health, Labour and Welfare. In this study, we evaluated the time spent on the different tasks of preparing prescription medicines by the CPSs such as entry of patients' information and contents of prescriptions, checking dispensing records, picking tablets, one-dose packaging, and packed-tablet inspection. The results showed that 71.4% of the total task time was spent on preparing one-dose packaging and packed-tablet inspection. We analyzed the effect of increasing the number of tablet cassettes in a fully-automatic tablet packing machine and introducing a packed-tablet inspection machine. It was found that they reduced the time spent by 12.8 and 43.1%, respectively. Our study concludes that to establish an environment in which pharmacists can concentrate on their primary role it is necessary to transfer the tasks that do not require pharmaceutical knowledge to CPSs, and utilize mechanization and ICT.