The activities of microorganisms seriously affect the growth, survival and production rates of fish (including crustaceans and shellfish). In fact, there are useful and harmful microbes in the aquaculture environment. One of the main concerns of people engaged in aquaculture is the methods for how to keep pathogenic microorganisms, mainly bacteria and viruses, away from fish rearing water. To this end many techniques for sterilization are commonly adopted and people tend to believe that these processes can eventually eliminate all microbes in water, and produce and maintain a nearly pure water quality. However, with these treatments the occurrence of pathogenic microorganisms which cause fish disease cannot be permanently removed. In spite of that, after such treatment microorganisms grow very quickly because of the presence of less antagonism among the bacterial populations. Furthermore, no one can anticipate what kind of microbial species may grow in the vacant space produced by the above treatments. The antagonism among microbes is a naturally occurring phenomenon through which pathogens can be killed or reduced in number in the aquaculture environment. Thus method, which is called biological control or biocontrol, is already familiar in the field of agriculture. In order to apply such biocontrol to the aquaculture environment, biocontrol agents (BCAs) that can repress the growth of pathogenic bacteria and viruses have been sought by many researchers. Although some results indicate a need for further studies of how individual microbes inhibit or promote fish health and growth, many other studies show BCAs that repressed the growth of pathogens and also promoted the survival rates of fish, including the identification of the microbes utilized. In this article, studies on the use of microorganisms as BCAs are reviewed in an attempt to provide an all encompassing understanding of the BCAs's role in aquaculture.
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