In 107 dogs with canine lymphoma, induction chemotherapy was performed with L-asparaginase(10,000 IU/m²)and prednisolone(median dose, 40mg/m²), and the initial responses were analyzed. The initial remission rate was high, at 92.3% (CR: 27.9% and PR: 64.4%), in 104 assessed cases. In terms of anatomical sites, the remission rate for multicentric lymphoma was significantly higher than that for cutaneous lymphoma(p=0.045). No significant differences were observed in remission rates by stage, substage, or prior corticosteroid administration. No severe side effects, such as anaphylaxis or clinically evident pancreatitis, were seen. The results suggested that L-asparaginase induction chemotherapy was an effective early induction agent for downstaging canine lymphoma.

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OBJECTIVES: The purpose of this study was to determine the survival time and overall benefits in dogs with bilateral thyroid carcinomas after performing unilateral thyroidectomy.
METHODS: Retrospective analyses of eight dogs with bilateral thyroid tumors treated with unilateral thyroidectomy at the Azabu University Veterinary Teaching Hospital Oncology Department between April 2000 and December 2008. Unilateral thyroidectomy was performed by removing the larger of the bilaterally formed tumors. The median survival period was calculated using the Kaplan-Meier product limit method.
RESULTS: The mean excised tumor size was 4.6 cm, ranging from 3 to 8 cm, while the non-operated mean tumor size was 2.5 cm(2-4 cm). The Kaplan-Meier analysis determined a median survival time of 593 days, ranging up to 1139 days. Five dogs received adjuvant chemotherapy, while one underwent palliative radiotherapy on the progressive non-resected tumor. There were neither local recurrences nor tumor-related deaths. Only one dog developed metastasis in the lung.
CLINICAL SIGNIFICANCE: This is the first study performed exclusively on bilateral thyroid carcinomas to assess the effects of unilateral thyroidectomy. Unilateral thyroidectomy(i. e., removal of the larger tumor, while leaving the non-excised tumor[<4cm])in place prolonged the median survival time to nearly 20 months without increasing the risk of complications as seen in bilateral-thyroidectomy.

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A 7-year-old, female, Miniature Dachshund underwent an excision of an anal sac apocrine gland adenocarcinoma without hypercalcemia, which was in the right side of the anal canal, 3×2.5×2.5 cm in size. A sublumbar lymph node was enlarged to 2.5 cm with neoplastic cells with moderate atypia. The area was irradiated in four fractions once a week for a total of 24 Gy. On day 498, the mass in the sublumbar lymph node area was enlarged to 3.2 cm, and two lung metastases were apparent. Therefore, partial resection of the pubis and ischium was performed to dilate the pelvic cavity on day 511. The bones were removed using a rongeur, the pubis was resected up to the junction with the ilium, and the ischium was resected up to the diameter of the rectum. The resected edges of bone were ground and smoothed. The muscles were not sutured, but the subcutaneous layer and skin were sutured. The evacuation difficulties and stool flattening disappeared on the day following the operation, and there was no evidence of lameness. On day 657 after the primary surgery, the evacuation difficulties recurred. On day 934 after the primary operation, it was reported that time required for defecation continued to increase gradually but that the general condition was good.

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