Background: Low serum albumin after esophagectomy has been reported to be associated with postoperative complications. There is controversy regarding the factors associated with serum albumin reduction after esophagectomy. This study was conducted to determine the degree of reduction in serum albumin level and the risk factors for reduction of serum albumin level after esophagectomy. Methods: After institutional ethics committee approval was obtained, a retrospective review was conducted of 121 patients who underwent thoracoscopic esophagectomy from January 2013 to June 2019. We evaluated relevant perioperative variables and serum albumin level before surgery and the next morning. Univariate analysis was performed to test the associations between perioperative factors and albumin reduction, and potential correlation factors were assessed by multiple regression analysis. Results: The median degree of albumin reduction after surgery was 35.1%(interquartile range, 30.8-40.5). Univariate analysis showed that operation time, intraoperative bleeding, and fluid intake until the next morning were factors associated with albumin reduction. Multiple regression analysis also showed that operation time, intraoperative bleeding and fluid intake until the next morning were independent factors related to albumin reduction. Conclusion: Serum albumin level decreased by about 35% after esophagectomy. Operation time, intraoperative bleeding and fluid intake until the next morning were independent factors related to albumin reduction.
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