Here, we report the case of opioid dependence in a 47-year-old man with intractable chest pain. The patient had been inappropriately administered high-dose opioids (equivalent to 600 mg of oral morphine) for eight years. After admission, opioid dosage was gradually tapered, and pain was managed using alternative analgesics. The patient's mental health symptoms were treated with antiepileptic and antipsychotic medications. After 42 months, opioids were discontinued. This case highlights the importance of careful opioid management and challenges associated with opioid withdrawal in dependent patients.

Eosinophilic gastroenteritis is primarily an allergic disease. This report describes a case of eosinophilic gastroenteritis successfully treated with Hangekobokuto. Patient: 30-year-old male, height 173 cm, weight 65 kg. The patient presented with severe diarrhea. He was diagnosed with eosinophilic gastroenteritis and started taking 30 mg of prednisolone (PSL), which was gradually tapered off. In 16 months after onset, we prescribed Hangekobokuto at our pain clinic, and the diarrhea improved within a week, and the PSL dose was gradually reduced. The patient's symptoms did not flare up. Hangekobokuto was effective for eosinophilic gastroenteritis. Soyo, which is included in Hangekobokuto, suppresses the production of IgE antibodies. The constituent crude drugs Hange and Bukuryo have been shown to inhibit histamine release and leukotriene release. These were effective in the treatment of eosinophilic gastroenteritis.