We studied possible factors to cause left ventricular rupture after mitral valve replacement and the prevention in eight patients of 1, 046 receiving mitral valve replacement between September, 1965 and August, 1991. The age at operation ranged from 43 to 67 years old (average 58 years old), and there were one man and seven women. According to the Treasure and Miller's classification, the type of rupture was type I in 5, type II in 2, and type III in 3. The onset time of rupture was immediately after cardiopulmonary bypass in 3 and at the time of chest closure in one. In four patients it occurred 11 hours, 14 hours, 18 hours and 25 hours after operation, respectively. In 8 patients, repair was performed with external closure under heart beating and in five patients with both internal and external closure during cardiac arrest under cardiopulmonary bypass. Two patients under cardiopulmonary bypass were successful for hemostasis, however, they died with low cardiac output syndrome, following to multiple organ failure 2 or 44 days after operation, respectively. The repair was not successful in 6 patients. In four patients the left ventricular rupture occurred immediately after hypertension and pathological findings showed severe myocardial degeneration of left ventricular muscle in all of them. These findings may suggest that hypertension after the operation is one of major factors to cause left ventricular rupture and thus the careful management of the systemic blood pressure after mitral valve replacement is effective to prevent the left ventricular rupture.

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Fifteen patients were operated on infective endocarditis (IE). We studied indication for operation, operative methods and results. There were 13 male and 2 female patients and the mean age of these patients was 48.5 years. 8 cases were inactive IE and 3 of them were prosthetic valve endocarditis (PVE). The patients consisted of 4 cases of aortic valve regurgetation, 2 cases of mitral valve regurgetation, 3 cases of PVE and 3 cases of VSD. Casual bacteria were positive for blood culture in 5 cases. The following bacteria findings were found: Streptcoccus viridans in 3 patients, gram-negative bacteria and Staphylococcus each in one case. Valve cultures were positive in 3 cases: There were gram-positive bacteria in 2 patients and Enterococcus in one case. Vegetations were present in all native valves and the echocardiogram was useful for these findings. There were 3 perioperative deaths (20%) and 2 of those patients were active PVE. All patients with IE who develop progressive congestive heart failure and cerebral emboli should have prompt valve relacement. In paticular active PVE still has high mortality rate.

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Long-term follow up (10.0yrs on average) is described of 33 patients with coronary aretry fistulae (CAF) without other cardiac disorders. Of 33 patients, nine cases demonstrated some electrocardiographic ischemic changes (group I), and other twenty-four cases showed no significant electrocardiographic changes (group II) clinically. Symptomatic, hemodynamic and angiographic findings showed no significant difference statistically between both groups. Thirty patients of small to moderate left-to-right shunt ratio (<50∼60%) showed hemodynamic and angiographic stability during the 10.0 years retrograde follow-up period on average. Of 33 patients, seventeen cases have underwent surgical closure of CAF since 1973 to 1990. Seven of the seventeen patients had showed significant myocardial ischemic changes before surgical treatments, and five of the seven cases showed definitive improvement of the electrocardiographic changes seemed to be derived from occlusion of the coronary steal blood flow after surgical operations. There were no operative deaths and no appearance of new myocardial ischemia following the surgical repairs. At present since not only it is unclear whether the CAF predisposes correlate coronary arteries to some premature atherosclerosises but also there are several reports of severe late risks of surgical repair of CAF, surgical indication in the patients of CAF with small-to-moderate left-to-right shunt shou ld be limited to the cases with such as definitive myocardial ischemia or evidence of infective endocarditis.

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From January, 1975 to December, 1989, 231 Björk-Shiley prostheses have been implanted in our hospital. During this period, we have experienced thrombosed valves in 0.69%/pt-yr for the aortic and 1.2%/pt-yr for the mitral position. Ten patients, four in the aortic and six in the mitral, have had thrombotic obstruction of a prosthetic valve. Seven cases of them had insufficient warfarin control. Clinical signs of thrombosed valves were dyspnea, thromboembolism and abnormal cardiac sound. Cineradiography was the most useful diagnostic method. Two cases underwent thrombolytic therapy, but one case died of cerebral complication and another needed an emergency cardiac operation 24 hours after the onset. Six survived among the eight surgical cases. We concluded that thrombosed valves mainly resulted from an insufficient anticoagulant therapy and an urgent surgical intervention would better be performed.

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Since January, 1981 to December, 1990, eight patients (one male, 7 female) of Stanford A type aortic dissection underwent surgical treatments with deep hypothermic circulatory arrest. The average was age 59.6 years (range 50 to 72 years). All of them were diagnosed with UCG and/or CT before operation. Two cases had already been in shock state due to cardiac tamponade. Three cases had aortic insufficiency and one had neurological deficit. After median sternotomy, right atrial-femoral artery bypass was established. Right atrium was incised and coronary sinus was cannulated. Then retrograde coronary infusion of cardioplegic solution was employed at a continuous flow rate of 20ml/kg/hr. The mean rectal temperature was 19.6°C and the mean circulatory arrest time was 35.5min (22-58min). Two of eight cases died, because of DIC followed by necrotizing enteritis at 28th postoperative day, and prolonged shock state before operation. The rest were all survived without any neurological deficits. There were no severe complications related to deep hypothermia. We concluded that deep hypothermic arrest is safe and simple method, allows good inspection of operative field and makes it easier to repair the dissected aorta.

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To estimate the blood compatibility during extracorporeal circulation, we designed mock circulation system consisted of a membrane oxygenator and vinyl circuit with roller pump. Primed with 200ml Ringer's acetate and 200ml of fresh whole human blood, mock circulation was worked at flow rate 0.5l/min for 6hr. Heparin was not primed, oxygenator did not fill any gases and circulation was keeping at 37°C. The thrombin-antthrombin complex and fibrinopeptide-A showed progressive increase and fibrinogen correspondingly decrease. Nevertheless, the plasmin α2 plasmin inhibitor complex and D-dimer showed minimal changes within normal range in spite of increasing fibrinopeptide B β 15-42. We can not find any signs of secondary fibrinolytic activity. On the other hand, the platelet was persistently activated as shown statistically significant increase in β-thrombogloblin and platelet factor IV. Significant elevations of complement 3a and 4a were seen with increase of complement 5a and activated oxygen productivity by neutrophilic leucocytes. In conclusion, moderate and limited blood alterations occurred in mock cardiopulmonary bypass circuit.

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Fifty-five adult patients with atrial septal defect (ASD) were surgically treated. In the preoperative study, 6 patients showed high pulmonary artery systolic pressure (>50mmHg). However, there was no linear relation between PAP and age, nor between Q_p/Q_s and PAP. As for the additional surgical procedures, MVR (1), MAP (1), TAP (3), OPC (2) were carried out with ASD closure in 7 patients. Post-operative evaluation with echocardiography revealed increase in the left ventricular chamber size, decrease in the severity of tricuspid regurgitation and same grade mitral regurgitation compaired with pre-operative level. From these data, the prediction of the atrioventricular valve regurgitation after ASD closure seemed to be difficult just from the preoperative evaluation, Transesophageal echocardiography was useful for the evaluation of residual atrioventricular valve regurgitation during operation in the cases of ASD with over II grade regurgitation preoperatively.

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We performed tricuspid annuloplasty aggressively in association with mitral and combined mitral and aortic valve disease. Because tricuspid regurgitation (TR) may produce significant morbidity if not corrected. From March 1986 to September 1990, for the purpose of studying the clinicopathology of the biopsied right ventricular myocardium in 54 patients with mitral valvular disease, the diameter of right ventricular myocardial cells and diffuse interstitial fibrosis of biopsied myocardium were measured quantitatively. The degree of diffuse interstitial fibrosis was assessed by the point-counting method, and mean percentage fibrosis (% fibrosis) was noted as 16.1%, % fibrosis was correlated with the severity of TR (r=0.36). Mean diameter of right ventricular myocardial cells was 19.3μm in size. The diameter of right ventricular myocardial cell was correlated with pulmonary arterial pressure (r=0.51). More aggressive narrowing of tricuspid valve ring using DeVega's method was performed on 39 of 54 patients. The evaluation of TR was done by Doppler echo. Postoperative residual TR was observed in four patients of total postoperative patients within mean follow-up period of 41.0 months. In the 4 patients, % fibrosis were in high % fibrosis (>20%). In comparison to the group with low % fibrosis (<15%) (n=27), the group with high % fibrosis (>20%) (n=9) was more serious in severity of TR by Doppler echo (2.4 vs. 1.7), age (58.2 vs. 51.6), NYHA classification (3.2 vs. 2.6) before surgery. In conclusion, open right ventricular myocardial biopsy findings suggest that the degree of myocardial fibrosis is correlated with severity of tricuspid regurgitation. And the patients whose % fibrosis are more than 20% are presumed poor right ventricular function. The diameter of right ventricular myocardial cell is correlated with pulmonary arterial pressure, that is, right ventricular hypertrophy is associated with pulmonary hypertension.

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We have used absorbable suture material for the repair of pediatric cardiovascular anomalies where subsequent growth of the suture line was requied since 1986. We reviewed long-term results of three groups of patients using absorbable suture (1. cardiovascular surgery in the high-pressure areas, 2. semicircular annuloplasty for mitral regurgitation, 3. cardiovascular surgery in the low pressure areas). In group 1, six patients after Jatene procedure using PDS^® were examined. Subsequent growth of the neo-aortic anastomotis were well preserved without formation of pseudoaneurysm 6-56 (average 18.6) months after the operation. In group 2, seven patients with mitral regurgitation (mitral valve regurgitation 4, endocardial cushion defect 3) were examined. The semicircular annuloplasty was applied using Vicryl^® and Dexon^® and mitral regurgitation was improved and in two patients normal growth of the mitral annulus was recognized 4 and half years after the operation. In group 3, sixteen patients in the repair of total anomalous pulmonary venous drainage (Darling type I, III) using PDS^® were examined. Pulmonary venous obstruction were encountered 1 and 5 months after the anastomotis between common pulmonary vein and left atrium in two patients and anastomotic stenosis was thought to be induced by tissue overgrowth. On the basis of our clinical experiences, we believe that application of absorbable suture in pediatric cardiovascular surgery in the high-pressure areas could be recommended as an alternative treatment, but that should be avoided in the neonatal small low-pressure areas on the assumption that anastomotic stenosis might be induced by tissue overgrowth.

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We have experienced 3 cases of valvulectomy without prosthetic replacement. All patients had active infective endocarditis. Clinical states of the patient who received pulmonary valvulectomy and of the other who received partial tricuspid valvulectomy are stable in the late phase. They have no cardiomegaly. The patient who received total tricuspid valvulectomy has progressive cardiomegaly. It seems that the volume overload due to the regurgetant flow in the tricuspid position causes the dilatation of the right heart. Tricuspid valvuloplasty with remained tissue or with pericardial patch may be more recommendable.

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A case of isolated left coronary artery ostial stenosis treated successfully by the saphenous vein patch plasty is reported. A 49-year-old woman was referred for surgery because of unstable angina with subendcardial infarction on ECG. Coronary angiogram showed isolated severe stenosis of left coronary artery ostium without stenotic lesion in the periphery and right coronary artery. At surgery, the aorta was incised obliquely downward to the left coronary ostium and this incision was further extended 8mm distally in the main trunk. Atheromatous left coronary ostium was enlarged with the saphenous vein patch. Postoperatively, angina disappeared and aortic root angioram revealed a well dilated ostium. At 1 year follow-up, the patient remains asymptomatic.

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A 42-year-old female was admitted complaining of a pulsating mass of her left upper arm for two years. As she had played volleyball, she hit a ball with her upper arm accidentally for many times. The arteriogram showed a 30×35mm sized brachial artery aneurysm. Replacement of brachial aneurysm with saphanous vein graft was performed. Histologically, the aneurysmal wall consisted of three layers of arterial wall and had multiple breaks in continuity of the elastic layer. We diagnosed it was a true traumatic aneurysm caused by repetitive blunt injury. The causes and etiology of the brachial artery aneurysms were discussed.

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A case of tricuspid regurgitation due to nonpenetrating chest trauma was presented. A 58-year-old man who had an episcde of a traffic accident 18 years ago was admitted because of the edema of the lower extremities and easy fatigability. On physical examination, engorgement of the jugular vein, enlagement of the liver and the slight edema of the lower extremities were observed. Systolic regurgitant murmur with Rivero-Carvallo sign was audible. Chest X-ray film revealed marked cardiomegaly and electrocardiogram presented atial fibrillation and complete right bundle branch block. Two-dimentional echocardiography revealed marked dilatation of the right atrium and ventricle, and systolic exertion of anterior and posterior leaflets of tricuspid valve. On cardiac catheterization, right atrial v wave was 23mm Hg. At operation, the pericardium was adheded to the epicardium, and the chorda tendae of the anterior and posterior leaflet were ruptured. Tricuspid valve replacement with 33mm Carpentier-Edwards pericardial prosthetic valve was performed without any complications. To the best of our knowledge, this is the 19th operated case of traumatic tricuspid regurgitation in Japan.

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The authors encountered 2 rare cases of adventitial cystic disease of the popliteal artery. Case 1 was a 51-year-old woman with dull pain in the lower limbs during walking. Case 2 was a 34-year-old man with numbness in the lower limbs on bending his knees. In both cases, angiography showed crescent stenosis, and computed tomography (CT) showed cyst-like lesions about the artery. Magnetic resonance imaging (MRI) indicated the lesions to have high density at T 2 imaging. With a diagnosis of adventitial cystic disease, cystectomy was conducted with satisfactory results. Adventitial cystic disease is rare and only 43 cases have so far been reported in this country. All of these were reviewed to clarify the characteristics of this disease. Its clinical symptoms often resemble those of arteriosclerosis obliterans (ASO) as intermittent claudication, but it differs from ASO in that it is usually achieved cure by cystectomy alone and seldomly required bypass operation. In the case of intermittent claudication in young patients, adventitial cystic disease should be diferrentiated from ASO.

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Thirty-nine years old woman had a severe renovascular hyper-tension with Takayasu's arteritis Her left renal artery stenosis was treated with percutaneous transluminal angioplasty (PTA) three times. Six months after the third PTA, the left renal artery was occluded, and left renal failure occurred. Aorto-renal bypass surgery with a prosthetic graft was performed. Blood pressure dropped to normal range, and left renal function began to recover. Although PTA is an effective method in the treatment of renovascular hypertension, an incidence of restenosis after PTA is higher in Takayasu's arteritis rather than atherosclerotic lesions. Five months after renal revascularization, hypertension recurred in this case. However the aorto-renal bypass graft was patent accompanied by no symptoms. This aorto-renal bypass surgery can be considered effective in this condition.

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A 6-year-old boy underwent one stage operation for atrial septal defect (ASD) and funnel chest. The procedure began with removal of cost-sterno complex (plastron) following median skin incision. Plastron was kept in cold saline with antibiotics during ASD closure, and sterno-costal elevation method was performed. Simultaneous operation for heart disease and funnel chest is profitable in preventing postoperative circulatory or respiratory complications, in avoiding problems of two stage operation such as adhesion and mental stress of the patients. In addition, wide exposure and easy approach to the heart is available with this one stage procedure. Although current refinement both of cardiac and thoracic surgery has encouraged the possibility of simultaneous corrections for heart disease and funnel chest, much precautions against bleeding and infection are necessary for the satisfactory surgical result.

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The supracardiac type is the most common total anomalous pulmonary venous connection (TAPVC) and is thought to be relatively rarely accompanied by pulmonary venous obstruction. An ascending vertical vein usually passes anterior to the left pulmonary artery, connecting to the brachiocephalic vein without obstruction. Now we report two cases in which the vertical vein passed between the left pulmonary artery and left bronchus with severe pulmonary vein obstruction in neonate. The cases are 12-day and 8-day males both of which were diagnosed mainly by UCT and underwent a succesful emergency operation. The former case with more severe pulmonary congestion than the later, had slower improvement of respiratory function and mild pulmonary hypertension after operation. The ascending vertical veins of both cases are compressed between left pulmonary artery and left main bronchus and then the pulmonary venous obstruction will appear and increase pulmonary hypertension. Resultant distention of the pulmonary artery will cause greater compression of the vertical vein. This will create a “hemodynamic vise.” For these cases, an earlier operation is required at the point of post-operative recovery.

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A 47 year-old man with frequent attacks of ventricular tachycardia (VT) due to arrhythmogenic right ventricular dysplasia (ARVD) developed severe right heart failure following cryoablation of the multiple VT focuses. Inotropic support and intraaortic balloon pumping failed to maintain the systemic circulation, so that we performed the right heart bypass (RHB) using a heparin-coated tube and roller pump. With the use of RHB, systemic circulation improved. We attempted to wean the patient off after 14 days RHB support. However this was unsuccessful because of poor RV function, and RHB was recommenced. The patient finally died of multiple organ failure on the 21st postoperative day, but the major organ function was well maintained for at least two weeks. The heparin-coated tube and roller pump system is easy to handle, and is suitable as a short term lifesaving adjunct for severe right ventricular failure.

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We applied a new circulatory support system to three patients with descending aortic operation between 1989 and 1990. The new system consisted of a polyvinylchloride tube coated with hydrophilic heparinized polymer and a roller pump. Low doses of heparin (0.5mg/kg) were administered in two patients and none in one patient before aortic bypass. The aortic crossclamping time ranged between 52 and 64 minutes. In two patients, whose inflow cannulae were 18Fr. or 20Fr., successful bypass flow exceeded 2l/min and optimal distal aortic pressure were maintained during aortic cross-clamping. The postoperative courses of these patients were uneventful, free from thromboembolic episodes and subsequently discharged from hospital. Furthermore, postoperative careful examination revealed no thrombus formation occurred in the three devices. In conclusion, our new simple, antithrombogenic circulatory system is extremely useful for descending aortic operations.

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We experienced a very rare case in a 26-year-old man who underwent surgery for bilateral atrial myxomas. Moreover, his initial symptoms were due to acute myocardial infarction, which strongly suggested coronary artery embolization. Transesophageal echocardiography revealed not only left atrial myxoma at posterior wall, but also right atrial myxoma at the fossa ovalis which had not been detected by transthoracic echocardiography. At surgery, both left and right atriotomy was performed and bilateral atrial myxomas were completely removed. We emphasized that transesophageal echocardiography was very useful in detecting the location of myxomas, and that surgical exploration of the right atrium would have been necessary even if left atrial myxomas had not existed at the atrial septum.

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