Dental Journal of Iwate Medical University
Online ISSN : 2424-1822
Print ISSN : 0385-1311
ISSN-L : 0385-1311
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Volume 26, Issue 1
Displaying 1-13 of 13 articles from this issue
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Special Review
Review
Originals
  • Influence of Cisplatin Exerted on the Telomerase Activity of Mice with Cancer
    Reiju Kobayashi
    2001 Volume 26 Issue 1 Pages 23-32
    Published: April 28, 2001
    Released on J-STAGE: March 25, 2017
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.26.1_23
    JOURNAL FREE ACCESS
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    Telomerase is an enzyme that adds TERT proteins and telomere repeat sequences to the end of chromosomes that make up RNA sub-units. This enzyme participates in the proliferation of cell division. Not found in normal tissues, high activity is shown in malignant tumors and tissues related to generative cells. This study analyzed the influence exerted on telomerase activity (TA) by anticancer agents and examined the utility of TA as an index of anti-tumor effects. It also examined c-myc involved in the TA mechanism, bcl-2 involved in apoptosis inhibition and the emission of each mRNA. In our a results, TA was not detected in normal mouse skin tissue, but high activity was observed in the mice’s carcinoma tissue within the squarnous cells. Also, on observing significant rises in the enhancement of tumors by TA, it appears to be deeply involved in the growth of cancer. With the administration of cisplatin, TA falls off significantly and the growth of tumors is inhibited. This shows that TA may be useful as an index for the anti・cancer effects of cisplatin. Myc proteins are involved in the transcription factor of tert genes. In this research the reduction in emissions of c-myc mRNA through the administration of cisplatin is shown in the involvemellt of TA of Myc proteins. Also, our resuits suggest that tumors may tend to reduce when restrained by apoptosis through reductions in bcl-2mRNA emissions.
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  • The mechanism of hypoxic constriction in isolated porcine pulmonary arteries
    ― with special reference to the endothelium and nitric oxide ―
    Yu Sato, Yoshiaki Kuji
    2001 Volume 26 Issue 1 Pages 33-43
    Published: April 28, 2001
    Released on J-STAGE: March 25, 2017
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.26.1_33
    JOURNAL FREE ACCESS
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    1. Hypoxic pulmonary vasoconstriction (HPV) plays an important role as a physical regulator in matching pulmonary perfusion to ventilation preventing systemic hypoxemia. But its precise mechanisrn is unkown.
    The aim of the present study is to investigate the cellular mechanisms and potential mediators involved in hypoxic constriction of porcine pulmonary arteries.
    2. Pulmonary arteries (internal diameter 2-3mm) were isolated from porcine lungs, and loaded with fura-2/AM, a Ca2+. indicator dye、 These artery rings were suspended in an organ chamber flooded with physiological salt solution on a microscope stage of a Ca2+ imaging spectrofluorimetric system. The light emission ratio of fura-2 for measurement of changes in intracellular calciurn levels ([Ca2+]i) and the isometric tension of the ring were measured simultaneously. Hypoxia was induced by flooding the reserved chamber with 95%N2 and 5%CO2 gas mixture.
    3. Hypoxic constriction and increases in [Ca2+]i were observed in the endothelium-intact rings under precontraction with 10-6M noradrenaline. In contrast, there were no hypoxic changes under precontraction with 90mM KC1.
    4. In the endothelium-denuded rings which were not relaxed with acetylcholine, hypoxia caused no changes in constriction and [Ca2+] i
    5. Hypoxic vasoconstriction of endothelium-intact rings was abolished by L-NAME, an inhibitor of nitric oxide synthetase.
    6. These results suggest that hypoxic constriction of isolated pulmonary artery of porcine lungs is induced partially by inhibition of the release of nitric oxide from the endotheliurn.
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Case reports
  • Acase report of unerupted mandiblllar second premolar migrating under the coronoid process
    Naoki Kudoh, Kazuro Satoh, Yukio Seino, Hiroyuki Miura
    2001 Volume 26 Issue 1 Pages 44-49
    Published: April 28, 2001
    Released on J-STAGE: March 25, 2017
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.26.1_44
    JOURNAL FREE ACCESS
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    In the process to permanent dentition, when the same teeth on the right and left sides erupt from the gingiva at about the same time, it is not uncommon to find the mandibular premolar impacted, displaced or unerupted. However, there is the possibility of the healthy growth of dentition causing obstruction, occlusion, and maxillofacial morphology.
    We report the case of a boy, 11years and 10months old, in whom the unerupted mandibular first and second premolars migrated forward in a distal movement. The latter moved up the ramus of the mandible to the coronoid process. We considered that the distal movement caused by loss of the posterior deciduous tooth ; the warming of the gingiva and the cortical bone ; the loss of remaining arch space available for eruption ; and the imbalanced mechanism of eruption.
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