Vitamin C (VC, L-ascorbic acid) transport is mediated by specific transporters, such as sodium-dependent vitamin C transporter (SVCT) 1 and 2. SVCT1 and 2 have a functional role in secondary active transport of VC from the outside to the inside of cells at the expense of sodium electrochemical gradient across the cell membrane. Recent studies revealed that the effect of SVCTs gene polymorphisms on risk of preterm birth and any diseases. Moreover, some paper reported that the effect of SVCTs gene polymorphisms on VC concentration in human blood and interactions with other antioxidant related genes. In this paper, we review recent insights into the relationships between SVCTs gene polymorphisms and health and disease risk.