VITAMINS
Online ISSN : 2424-080X
Print ISSN : 0006-386X
Vitamin E absorption mediated by NPC1L1, a cholesterol transporter
Tappei TakadaHiroshi Suzuki
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JOURNAL FREE ACCESS

2010 Volume 84 Issue 8 Pages 376-383

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Abstract
Niemann-Pick C1-like 1 (NPC1L1) is essential for the intestinal absorption of cholesterol and is recognized as a pharmacological target of ezetimibe (Zetia[○!R]), a cholesterol absorption inhibitor clinically used for the treatment of dyslipidemia. Based on the hypothesis that some lipophilic molecules may be taken up in the intestinal lumen via a pathway shared with cholesterol, we tested some fat-soluble molecules and obtained the data suggesting that NPC1L1 has the ability to transport vitamin E and that ezetimibe is able to inhibit the intestinal absorption of vitamin E. This review article describes the basis and recent topics of NPC1L1 and its vitamin E transport.
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© 2010 THE VITAMIN SOCIETY OF JAPAN

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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