日本人非肥満2型糖尿病患者のインスリン抵抗性は内臓, 皮下脂肪蓄積, 血清中性脂肪値と相関する

浦川 英己; 勝木 顕; 松本 和隆; 丸山 範子; 森岡 浩平; 北川 良子; 堀 恭子; 中谷 中; 矢野 裕; 足立 幸彦; 住田 安弘

doi:10.11213/tonyobyo1958.47.277

Insulin Resistance Is Associated with Visceral Subcutaneous Adiposity and Serum Triglyceride in Nonobese Japanese Patients with Type 2 Diabetes Mellitus

Hideki Urakawa, Akira Katsuki, Kazutaka Matsumoto, Noriko Maruyama, Kohei Morioka, Nagako Kitagawa, Yasuko Hori, Kaname Nakatani, Yutaka Yano, Yukihiko Adachi, Yasuhiro Sumida

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JOURNAL FREE ACCESS

2004 Volume 47 Issue 4 Pages 277-282

DOI https://doi.org/10.11213/tonyobyo1958.47.277

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Abstract

To determine the relationship between insulin resistance and visceral subcutaneous fat adiposity or serum triglyceride (TG) in nonobese Japanese patients with type 2 diabetes mellitus, we conducted a euglycemic hyperinsulinemic clamp study in 149 patients with type 2 diabetes.Visceral and subcutaneous fat were measured by computed tomography (CT).Glucose infusion rate (GIR;index of insulin sensitivity during the euglycemic hyperinsulinemic clamp study) correlated significantly negatively with visceral (r =-0.254, p<0.01), subcutaneous fat (r=-0.261, p<0.01) or serum TG (r=-0.180, p<0.05).Visceral fat areas correlated significantly positively with serum TG (r 0.299, p< 0.01). These results suggest that visceral subcutaneous fat accumulation and serum TG may contribute to the development of insulin resistance in nonobese Japanese patients with type 2 diabetes mellitus.

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