A case of insulin autoimmune syndrome is reported. A 78-yr old man came to us complaining of cold sweats and palpitations around noontime for 2 months.
Fasting blood glucose was 53mg/dl, and fasting IRI determined by the double antibody method was 320μU/ml. He had never received insulin injections.
The percent ¹²⁵ I-insulin binding was 70%, and a large amount of total IRI extracted by the acid ethanol method was observed.
This patient possessed HLA-DR4/DQ3 bearing DRB10403/DQA10301/DQB10302, whereas almost all patients with insulin autoimmune syndrome have been reported to possess HLA DR4/ DQ3 bearing DRB10406/DQA10301/DQB10302.