Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Two Cases of Secondary Central Diabetes Insipidus Associated with Hyperosmolar Diabetic Coma
Tomohiro MitsukawaHirotaka ToshimoriHideki YamaguchiSeiichi EnokiKuninobu NakatsuruShigeru Matsukura
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1992 Volume 35 Issue 1 Pages 31-36

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Abstract
Reports of an association between diabetes insipidus and hyperosmolar diabetic coma are very rare. We have recently encountered 2 cases of diabetes insipidus associated with hyperosmolardiabetic coma.Hypopituitarism and diabetes insipidus developed after surgical treatment of craniopharyngioma. Before the development of hyperosmolar diabetic coma the patients complained of thirst and polydipsia probably due to poor control of diabetes insipidus. A diagnosis of hyperosmolardiabetic coma was made on the basis of clinical and laboratory findings. The patients were successfully treated for their glucose intolerane with half-normal saline solutions, insulin and desmopressin, and eventually with diet alone. We believe that glucose tolerance should be carefully and serially monitored in patients with diabetes insipidus.
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