Abstract
Reports of an association between diabetes insipidus and hyperosmolar diabetic coma are very rare. We have recently encountered 2 cases of diabetes insipidus associated with hyperosmolardiabetic coma.Hypopituitarism and diabetes insipidus developed after surgical treatment of craniopharyngioma. Before the development of hyperosmolar diabetic coma the patients complained of thirst and polydipsia probably due to poor control of diabetes insipidus. A diagnosis of hyperosmolardiabetic coma was made on the basis of clinical and laboratory findings. The patients were successfully treated for their glucose intolerane with half-normal saline solutions, insulin and desmopressin, and eventually with diet alone. We believe that glucose tolerance should be carefully and serially monitored in patients with diabetes insipidus.