Coagulation-fibrinolytic activities were assayed in 45 diabetics. Platelet Factor 4 increased in 77.8 antithrombin III decreased in 61.5%, fibrinogen increased in 100% and antiplasmin decreased in 65.9% of all cases.
A relative coagulative tendency without comparable in fibrinolysis seemed to exist in diabeticsirrespective of age, duration, treatment and serum lipid level.
These changes seem to be 7 “the preceding state of chronic low grade disseminated intravascular coagulation”(Ultin, O. N.: 1975) and can possibly contribute to the pathogenesis of the diabetic vascular complications, especially of microangiopathy.