The procoagulant from human urine (urine factor, UF) was purified by the method of von Kaulla and Aoki. Subjects were divided into four groups. A: eight normal volunteers, B: eleven diabetics associated with arteriosclerotic complication, C: ten diabetics with diabetic microangiopathy and D: eight patients with secondary diabetes induced by adrenocortical hormone The mean level of UF in A, B, C and D were 3.51, 3.73, 1.62 and 4.05 mg/day respectively. The negative correlation between UF excretion and duration of diabetes mellitus was observed (r=-0.38, p<0.05). The correlation between UF excretion and creatinine clearance was also observed (r=0.419, p<0.05). The UF levels of some patients in group C decreased during warfarin treatment.
It is concluded that UF levels increased in the early stage of diabetes mellitus which seems to reflect the active intraglomerular coagulation, on the other hand it decreased in the later stage which seems to reflect the inactive state.