We herein report the case of an obese 54-year-old woman with type 2 diabetes (T2DM) following bilateral transfemoral amputation. At 43 years of age, she underwent bilateral transfemoral limb amputation. At 50 years of age, she was diagnosed with T2DM, and therapy with sitagliptin and metformin was initiated, but her obesity and glycemic control deteriorated due to poor dietary compliance. In September X, her HbA1c became 9.6 %, and she was admitted to our hospital in October. Her height was 114.0 cm, and her body weight was 58.8 kg against an estimated standard body weight of 35.0 kg as a bilateral transfemoral amputee. We estimated her caloric intake would be 1200 kcal using the Harris-Benedict formula and measurements of her oxygen consumption. Liraglutide 0.3 mg was initiated instead of sitagliptin, which resulted in an improved glycemic control. Traumatic lower limb amputees are at a high risk of developing an increase in body fat and cardiovascular disease because of sedentary behavior, a high caloric intake and adiposopathy. In the present case, the estimated caloric intake based on her lower limb amputee status and the administration of liraglutide to reduce her appetite in order to manage her body weight and cardiovascular events seemed effective.