ダプトマイシンによる急性好酸球性肺炎が疑われた糖尿病性足病変に伴う下腿蜂窩織炎の1例

村上 隆亮; 小山 泰司; 増井 秀行; 波床 朋信; 島村 清貴; 松田 優樹; 松尾 浩司; 南部 拓央; 米光 新; 武呂 誠司; 隠岐 尚吾

doi:10.11213/tonyobyo.57.264

Case Reports

A Case of Diabetic Foot Infection with Daptomycin-induced Acute Eosinophilic Pneumonia

Takaaki Murakami, Taiji Koyama, Hideyuki Masui, Tomonobu Hatoko, Kiyotaka Shimamura, Yuki Matsuda, Koji Matsuo, Takuo Nambu, Shin Yonemitsu, Seiji Muro, Shogo Oki

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JOURNAL FREE ACCESS

2014 Volume 57 Issue 4 Pages 264-270

DOI https://doi.org/10.11213/tonyobyo.57.264

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Abstract

A 56-year-old female with a six-year history of poorly controlled diabetes mellitus was admitted for septic shock with infectious diabetic foot ulcers. She was treated with antimicrobial agents, including daptomycin. Although her condition improved, she developed dyspnea and hypoxemia with bilateral pulmonary infiltrates one week after admission. She also exhibited eosinophilia and eosinophil-rich sputum. Her condition rapidly improved following the discontinuation of daptomycin. Therefore, the features of this case were consistent with a diagnosis of daptomycin-induced acute eosinophilic pneumonia. Daptomycin is a relatively new antimicrobial agent whose high degree of efficacy for diabetic skin and soft tissue infections and bacteremia has been proven in clinical trials. Increased attention should be paid to the rare but serious adverse effect of daptomycin-induced acute eosinophilic pneumonia.

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