超速効型インスリンを用いた強化療法における夕食前グラルギン注射の血糖安定化作用

中山 ひとみ; 加藤 智子; 賀来 寛雄; 新関 史; 迎 徳範; 江口 洋幸; 田中 佳世; 原 健人; 満崎 健志; 中山 聡; 広田 有俊; 山田 研太郎

doi:10.11213/tonyobyo.52.7

Original Article

Blood Glucose Stabilization by Predinner Insulin Glargine in Intensive Therapy with Rapid-Acting Insulin Analog

Hitomi Nakayama, Tomoko Kato, Hiroo Kaku, Fumi Niizeki, Tokunori Mukai, Hiroyuki Eguchi, Kayo Tanaka, Kento Hara, Kenshi Mitsuzaki, Satoshi Nakayama, Naotoshi Hirota, Kentaro Yamada

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JOURNAL FREE ACCESS

2009 Volume 52 Issue 1 Pages 7-11

DOI https://doi.org/10.11213/tonyobyo.52.7

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Abstract

To compare the effects of NPH insulin at bedtime and insulin glargine before dinner combined with premeal rapid-acting-insulin analog injections, we assessed daily plasma glucose profiles in 177 inpatients with Type 1 (n=61) or Type 2 (n=116) diabetes. We found no significant difference in doses of either rapid-acting-insulin analog or NPH/glargine, but Type 2 diabetes patients showed significantly lower post breakfast and post dinner glucose when injected with insulin glargine. Type 1 diabetes patients showed bedtime NPH associated with an elevated low blood glucose index at 03:00. Predinner glargine significantly reduced nocturnal hypoglycemic risk. These observations showed that predinner glargine combinated with rapid-acting-insulin analog acts more beneficially on postprandial hyperglycemia in Type 2 diabetes and nocturnal hypoglycemic risk in Type 1 diabetes than bedtime NPH in equivalent doses.

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