Do Fasudil and Losartan Treatments Improve EDH Mediated Coronary Dilation in Hypertensive Insulin Resistant Rats through Gap Junctions

James T. Pearson; Hirotsugu Tsuchimochi; Takashi Sonobe; Vijayakumar Sukumaran; Tadakatsu Inagaki; Keiji Umetani

doi:10.18957/rr.12.6.358

Section A

Do Fasudil and Losartan Treatments Improve EDH Mediated Coronary Dilation in Hypertensive Insulin Resistant Rats through Gap Junctions

James T. Pearson, Hirotsugu Tsuchimochi, Takashi Sonobe, Vijayakumar Sukumaran, Tadakatsu Inagaki, Keiji Umetani

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Keywords: coronary function, microvessels, gap junctions, diabetes, 2016B1064, BL28B2

JOURNAL OPEN ACCESS

2024 Volume 12 Issue 6 Pages 358-362

DOI https://doi.org/10.18957/rr.12.6.358

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Abstract

　We investigated in hypertensive diabetic rats the contributions of endothelium derived hyperpolarization (EDH) and nitric oxide to the maintenance of coronary perfusion and conduction of vasodilation to distal microvessels utilizing synchrotron microangiography. We found that both fasudil and combined fasudil-losartan treatment improved EDH and nitric oxide mediated microvessel dilation.

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