We design and demonstrate a microsystem powered by Vorticella. This research has been conducted in four steps: 1) actuation properties of a stalk and cilium have been characterized; 2) methods to integrate Vorticella with a microsystem have been developed; 3) a control system for Vorticella actuator has been developed; 4) a micromixer powered by cilia and a microvalve driven by a stalk are proposed, and their feasibility is confirmed. We showed fundamental principles of the devices. The proposed device will open a door to a new field of microsystems and be extended to a controllable biomicrosystem. Cell-based autonomous microsystem will be possible in the future by integrating cells with MEMS.