Atherosclerosis is one of the causes of cardiovascular diseases or celebrovascular disorders. Low density lipoprotein transport through an arterial wall and accumulation is considered as a main factor in the early stage of initiation of atherosclerosis. On the other hand, it is known that mechanical forces such as wall shear stress (WSS ) influence the uptake function of endothelial cells and the preferential site of atherosclerosis is associated with low WSS region.
   In this paper, to investigate the effects of WSS on mass transport, the blood flow and solute transport in the lumen and arterial wall are modeled taking account of the multi-layered structure of arterial wall. A shear-dependent hydraulic conductivity and permeability is employed. As a result, solute concentration in arterial wall increases in the areas where WSS is low. It shows that low WSS affects solute accumulation in the arterial wall and initiation of atherosclerosis. [This abstract is not included in the PDF]