A 50-year-old man admitted with lower abdominal pain and hematochezia was found to have an egg- sized tumor and tenderness in the left lower abdomen. Abdominal computed tomography showed intussusception of the sigmoid colon, in which an egg-sized elastic, hard, smooth tumor was found projecting into the colonic lumen by colonofiberscopy. Biopsy of the tumor showed Group 1 without carcinoma. Sigmoidectomy with D2 lymphnode dissection was done under preoperative diagnosis of sigmoid colon submucosal tumor combined with intussusception. Histopathologically, findings showed well-differentiated liposarcoma of the colon. The postoperative course was favorable and he discharged on postoperative day 23. Liposarcoma arising in the large intestine is rare, and this is only the fifth case of colon liposarcoma reported in Japan. We analyze these 5 reports, which suggest that well-differentiated liposarcoma may have a smooth surface and no metastasis. Pleomorphic liposarcoma may, however, have a polynodular irregular surface and invasive metastasis.