Abstract
A 16-year-old man was transferred to the hospital from a physician because of deteriorated diarrhea, melena, and difficult defecation lasting from his childhood. Endoscopy and barium enema showed a 5×3 cm polypoid lesion in the lower rectum. Features of biopsy specimens were compatible with mucosal prolapse syndrome of the rectum (MPS). Defecography showed abnormal perineal descent and rectal intussusception. Anorectal manometry showed a decrease in maximal capacity. We thought that the polypoid lesions of MPS had caused disordedred defecation, and performed transanal resection of the lesions. After the operation, discomfort after defecation disappeared and the disordered defecation was improved. Transanal resection is an effective option for the treatment of polypoid MPS in instances in which the presence of the lesion itself causes discomfort after defecation.