We describe a long survival case of multiple liver metastases from colonic cancer completely cured by intra-hepatic arterial infusion chemotherapy. A 65-year-old man was seen at the hospital because of constipation. Barium enema examination and colonoscopic examination showed a 2'type tumor that was 50cm proximal from the anal verge, on the sigmoid colon. Abdominal CT and ultrasonograpy showed four metastatic liver tumors in the bilateral lobes. Sigmoidectomy with lymph nodes dissection was performed. At operation, four metastatic liver tumors could not be resected. After the operation, an intrahepatic arterial catheter was indwelt. On a weekly schedule, 1, 500mg of 5-FU was administered over 5 hours by hepatic arterial infusion. After 23 courses of the chemotherapy, four metastatic liver tumors vanished. A total of 43 courses of the chemotherapy with a total dose of 69.5g of 5-FU was given. There have been free from any signs of recurrence as of more than 5 years 8 months after the operation. Intrahepatic arterial infusion chemotherapy for liver metastasis from colon cancer can produce an excellent effect like as this case.