Chemotherapy with combined administration of UFT and oral leucovorin has been reported to be effective for advanced colorectal cancer. We adopted this regimen for two cases of far advanced colorectal cancer and its efficacy was confirmed by diagnostic images and pathohistology. As to chemotherapy protocol, UFT (300mg/m²) and LV (100mg) were administered daily for consecutive 28 days as one course. Case 1: A 50-year-old man with a huge rectal cancer involving the urinary bladder was treated with oral UFT/LV for one course. After the chemotherapy, CT and magnetic resonance imaging (MRI) revealed a remarkably reduced tumor which allowed us to remove completely by a total pelvic exenteration. Histological evaluation of effect of the chemotherapy resulted in Grade Ib. Case 2: A 55-year-old man had an advanced cancer of the colon perforating into the abdominal space with hepatic metastasis. He was rescued by an emergency operation consisting of an partial resection of the transverse and descending colon and abscess drainage. Postoperative oral UFT/LV was induced for two courses. After the chemotherapy a significant reduction of the hepatic metastasis and an apparent decrease in CEA were observed. No adverse side effects other than mild diarrhea in case 2 were found. Therefore, oral UFT/LV can be a promising adjuvant chemotherapy before or after operation for far advanced colorectal cancer.