Even in Japan, the number of HIV (Human Immunodeficiency Virus) infected patients is rapidly increasing. Thus, the opportunity for health care workers to come in contact with HIV infected patients will increases on a daily basis. This paper will mainly discusses the treatment for HIV infected patients and operative indications. A total of 10 operations were performed on 9 patients at the Tokyo Metropolitan Komagome Hospital (2 AIDS patients and 7 asymptomatic HIV infected patients). We performed lung lobectomies, biopsies of the tumor, permutations of artificial joints, adhesiolysis of an ileus, cannulation of the hepatic artery, colostomy, and skin transplantation in our study. All patients were known to be HIV seropositive prior to operations. No operative deaths occurred. No statistical relationships were observed between the immune conditions of the patients, operating times, volume of blood losses and the existence of complications in this study. The operative indication is usually determined according to the CD4+cell count. Although one case did not meet the operative indication on the CD4+cell count basis, we were able to get a good result. In considering the patient's quality of life, the operative indications should be more flexible.