A STUDY OF TUMOR MICROVESSEL DENSITY AS PREDICTOR OF METACHRONOUS LIVER METASTASES ON CURATIVELY RESECTED COLORECTAL CANCER

Fumichika KITAMURA; Shigetoyo SAJI; Daizo FUKADA; Kiichi MIYA; Katsuyuki KUNIEDA; Yasuyuki SUGIYAMA; Motohisa KATOH; Masahiro HAYAKAWA; Kazuya YAMAGUCHI; Jun SANO

doi:10.3919/jjsa.59.1496

Fumichika KITAMURA, Shigetoyo SAJI, Daizo FUKADA, Kiichi MIYA, Katsuyuki KUNIEDA, Yasuyuki SUGIYAMA, Motohisa KATOH, Masahiro HAYAKAWA, Kazuya YAMAGUCHI, Jun SANO

Author information

Fumichika KITAMURA
Second Department of Surgery, Gifu University, School of Medicine
Shigetoyo SAJI
Second Department of Surgery, Gifu University, School of Medicine
Daizo FUKADA
Second Department of Surgery, Gifu University, School of Medicine
Kiichi MIYA
Second Department of Surgery, Gifu University, School of Medicine
Katsuyuki KUNIEDA
Second Department of Surgery, Gifu University, School of Medicine
Yasuyuki SUGIYAMA
Second Department of Surgery, Gifu University, School of Medicine
Motohisa KATOH
Second Department of Surgery, Gifu University, School of Medicine
Masahiro HAYAKAWA
Second Department of Surgery, Gifu University, School of Medicine
Kazuya YAMAGUCHI
Second Department of Surgery, Gifu University, School of Medicine
Jun SANO
Second Department of Surgery, Gifu University, School of Medicine

JOURNAL FREE ACCESS

1998 Volume 59 Issue 6 Pages 1496-1500

DOI https://doi.org/10.3919/jjsa.59.1496

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Abstract

To clarify the prediction of metachronous liver metastases on curatively resected colorectal cancers, tumor microvessel density was compared between 33 cases with postoperative liver metastases (meta-chronous group) and 66 cases without liver metastases (control group). Control group was frequency (1:2) matched with metachronous group for tumor location, depth of invasion, and histological type. Microvesels were immunohistochemically stained with anti-factor VIII monoclonal antibody and were counted in a×200 field. Microvessel density (MVD) of metachronous group was significantly higher than that of control group (36.1±5.21 vs. 31.9±5.62, p=0.0006). Receiver operating characteristic curve of MVD indicated that the most compatible cut-off value for liver metastases was 34. The positive predictive value of high MVD (_??_34) for metachronous liver metastases was 0.24. High MVD was significantly associated with lymph node metastases and histological stage. A significantly positive correlation was observed between MVD and PCNA LI. From the above results it is suggested that immunohistochemical study of MVD is useful for prediction of metachronous liver metastases on curatively resected colorectal cancers.

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