Although many CGE models have already been developed for analyzing climate policy in Japan, most of them only investigate national level impacts. However, impacts of emissions regulations are likely to vary considerably by region because there are large regional differences in household expenditure pattern and industry structure. To investigate regional impacts of greenhouse gas (GHG) emissions regulations in Japan, we construct a new multi-regional CGE model with 9 regions in Japan and estimate regional GHG emissions. We analyze the impact of a 1.0% reduction of GHG on regional GDP, welfare, and production. Our simulation shows that regions with a higher share of energy-intensive industries and thermal power generation incur a larger loss in GDP.