This study reviews recent advances and topics in the fields of otology, rhinology, pharyngolaryngology, and head and neck surgery in the Department of Otorhinolaryngology, Juntendo University School of Medicine. In otology, several animal model of genetic deafness have been developed and studied in order to promote further advances in clinical therapy. A new implantable hearing aid generated by magnetic power has been developed for clinical trial. This device would provide presbyacusis with a better amplification of hearing. Clinical works in the field of rhinology focus on surgical therapy for allergic rhinitis and chronic rhinosinusitis. Surgical modalities of allergic rhinitis include argon plasma ablation in the inferior turbinate and resection of the posterior nasal nerve. Minimally invasive surgery used using an endonasal endoscopic approach is being applied to treatment of chronic rhinosinusitis. In the field of pharyngolaryngology, patients with obstructive sleep apnea and snoring have been investigated by overnight sleep studies and a variety of medical managements and surgical procedures including nasal continuous positive pressure and laser-assisted uvulopalatoplasty have been applied with short-term stay. Head and neck carcinoma has been treated with multidisciplinary modalities of chemoradiation and surgery accompanied by plastic reconstruction to preserve quality of life.