It was 1913 when an enzyme was first incorporated into a laundry detergent, and it has passed over 100 years since then. During these years, the detergent formula and detergent enzymes have evolved remarkably in parallel. With the current trend toward SDGs and soaring raw materials prices, the detergent industry seems to be approaching a turning point. In this review, we would like to review the detergent development from the angle of the detergent enzyme development. In addition to that, we would like to give a perspective on the laundry detergent of the future.